麻醉Prilocaine 721-50-6有效疼痛放松主题
prilocaine个人资料
产品名称：Prilocaine
同义词：2-（propylamino）-o-propionotoluidid;
cas：721-50-6
mf：c13h20n2o
mw：220.31
einecs：211-957-0
产品分类：活性药物成分
包装：箔袋或要求
丙胺卡因的药理作用
Amide家族的局部麻醉药，其作用类似于利多卡因，但时间较长。没有血管扩张作用，毒性较小，积累量也很小。
丙胺卡因的药代动力学
相当一部分肺代谢或分离（隔离），在体内通过肝脏代谢的快速降解，毒性比利多卡因。
丙胺卡因的适应症
用于硬膜外麻醉，阻断麻醉和浸润麻醉。
丙胺卡因禁忌症
贫血，先天性或自发性变性血红蛋白患者禁用，孕妇慎用。
注意事项
目前临床不再常用，主要用于局部浸润麻醉和局部静脉麻醉。
2.最大600mg。
丙胺卡因的不良反应
当剂量超过600mg时，邻甲苯胺的代谢，血红蛋白的血红蛋白降低，血红蛋白降低超过1.5g / dl，临床可能是紫osis，血红蛋白尿等并发症。如果是1mg / kg的亚甲基蓝可以有效治疗高铁血红蛋白血症。
丙胺卡因的用量
用1％溶液进行渗透麻醉;各种神经阻滞或硬膜外麻醉用2％或3％溶液。
丙胺卡因与其他药物的相互作用
在接受可能引起高铁血红蛋白血症的其他药物（如磺胺类药物）的患者中，丙胺卡因会加重高铁血红蛋白的形成。见盐酸利多卡因。

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Anesthesia Prilocaine 721-50-6 Effective Pain Reliver Topical
prilocaine Profile
Product Name: Prilocaine
Synonyms: 2-(propylamino)-o-propionotoluidid;
CAS: 721-50-6
MF: C13H20N2O
MW: 220.31
EINECS: 211-957-0
Product Categories: Active Pharmaceutical Ingredients
Packing:Foil bag or as requirments
Pharmacological effects of prilocaine
Amide family of local anesthetics, the role of similar to lidocaine, but a longer time. No vasodilator effect, less toxic, accumulation is also small.
Pharmacokinetics of prilocaine
A considerable part of the lung metabolism or separation (sequester), in the body by the rapid degradation of the liver metabolism, toxicity than lidocaine.
Indications of prilocaine
For epidural anesthesia, block anesthesia and infiltration anesthesia.
Contraindications of prilocaine
Anemia, congenital or spontaneous degeneration of hemoglobin patients disabled, pregnant women with caution.
Precautions
1. Currently no longer commonly used clinically, mainly for local infiltration anesthesia and local intravenous anesthesia.
2. A maximum of 600mg.
Adverse effects of prilocaine
When the dose of more than 600mg, the metabolism of o-toluidine, hemoglobin reduction for the hemoglobin, and the blood methemoglobin more than 1.5g / dl, the clinical may be cyanosis, hemoglobinuria and other complications. In the event, to be 1mg / kg of methylene blue can be effective treatment of methemoglobinemia.
Dosage of prilocaine
Infiltration anesthesia with 1% solution; a variety of nerve block or epidural anesthesia with 2% or 3% solution.
Interaction of prilocaine with other drugs
In patients receiving other medications (such as sulfonamides) that can cause methemoglobinemia, prilocaine can aggravate methemoglobin formation. See lidocaine hydrochloride.

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