Oral Anti Estrogen Nolvadex for Breast Cancer Treatment
口服抗雌激素Nolvadex用于乳腺癌治疗
议价
加入意向| 型号。 | 10540-29-1 |
| 定制 | 非定制 |
| 适合 | 成人 |
| 纯度 | >99% |
| 出现 | 白色结晶粉末。 |
| 别号 | 诺瓦得士;谭，他莫昔芬Citrat |
| 规范 | gmp，sgs，iso，kosher |
| HS编码 | 6809900000 |
| 粉末 | 是 |
| 证明 | gmp，iso 9001，usp，bp |
| 州 | 固体 |
| 产品名称 | 诺瓦得士 |
| 用法 | 它用于抗雌激素诱导诱导 |
| 商标 | whsm |
| 起源 | 中国 |
标签 :
女性减肥类固醇
,类固醇减肥
口服抗雌激素他莫昔芬柠檬酸盐/乳腺癌乳腺癌治疗CAS 10540-29-1
1.抗肿瘤药物原料，适用于乳腺癌.Nolvadex降低雌激素水平是不正确的：相反，它阻断雌激素受体的雌激素，而在作为拮抗剂的那些组织中，它使得受体不起作用。 Nolvadex不是合成代谢类固醇，而是用于管理类固醇的副作用。
他莫昔芬在早期治疗完成后也可用于治疗乳腺癌。早期治疗可以包括手术，放射和化疗。他莫昔芬可能会使癌症扩散到身体其他部位。可能会减少新乳腺癌的机会。
3.他莫昔芬是一种抗癌药物，用于治疗妇女和男性的乳腺癌。
Clomid vs nolvadex 循环评论
Nolvadex和Clomid是世界上最受欢迎的两种选择性雌激素受体调节剂（SERM），也是许多性能增强运动员补充计划的一部分。在许多方面，Nolvadex和Clomid是相同的;事实上，可以使用任何一种形式来获得相同的结果，假定剂量应用于根据您使用的配合进行匹配。毫无疑问，Nolvadex和Clomid最常见的用途是在所谓的后循环治疗（PCT）期间，合成代谢类固醇循环结束并恢复过程开始的时间段。虽然PCT期间是这些非常有效的SERMs的常见使用点，但是在实际的合成代谢类固醇循环本身期间将有一些补充，以抵抗可能的副作用，例如男子女性型乳房发育症。 Nolvadex和Clomid都可用于预防周期性男子乳腺发育，但它们不等于其他选择的功能，通常最好在PCT角色中服务。
Nolvadex和Clomid的力量：
多年来，许多人都认为Nolvadex是更好的SERM，比Clomid更有效，但这是一个不准确的声明。毫无疑问，毫升毫升毫升Nolva，因为它通常比Clomid更强; 1毫克Nolvadex携带比1毫克Clomid更多的效力。考虑到这一点，如果我们等于剂量，意思是，我们增加了Clomid的剂量以匹配Nolva在每毫克基础上的效力，我们在很大程度上具有相同的效果，相同的结果;那些通常不喜欢Clomid的人，特别是在PCT期间通常根本不够用。
Nolvadex和Clomid for PCT：
PCT的目的是简单和双重的;刺激由于使用合成代谢类固醇而被抑制的天然睾酮产生，并简单地使身体正常化以保持健康。当然，大多数人也关心他们从表现周期中获得的成果，但是有效地实现前面提到的两个因素将会促进正面和积极的方式。
实施Nolvadex后循环治疗：
我们不会简单和任意地结束我们的合成代谢类固醇循环并开始我们的后循环恢复;您必须了解您正在使用的类固醇以确定时间，这非常重要。如果您的NOLVADEX后期循环计划太早开始，您的系统中仍然有很多抑制性合成代谢类固醇，整个恢复过程将会浪费。
如果您的周期以短酯类固醇类固醇结束，您可以在上次注射2-3天后开始恢复过程;无论您是否要包括hCG，您仍然会在合成代谢类固醇循环结束后2-3天开始。然而，如果您的周期结束，任何长酯类固醇会改变;在这种情况下，如果要将hCG纳入您的Nolvadex后循环计划，您将在最后一次注射甾体后十天开始使用hCG;如果您的周期以非常长的酯类齿轮（如Deca-Durabolin）结束，则等待整整两周可能是明智的。如果您的周期以长酯类固醇结束，并且您不包括hCG，则需要等待2周才能使Nolvadex后循环治疗开始，如果在循环结束时使用类固醇如Deca-Durabolin，则3周是最佳的。
什么是nolvadex抗雌激素类固醇？
他莫昔芬通过其活性代谢物4-羟基他莫昔芬是乳腺组织中雌激素受体的拮抗剂。在其他组织如子宫内膜中，其表现为激动剂，因此可以被表征为混合的激动剂/拮抗剂。他莫昔芬是绝经前妇女激素受体阳性乳腺癌的通常内分泌（抗雌激素）治疗，也是绝经后妇女的标准，尽管芳香酶抑制剂也经常用于该设置。
一些乳腺癌细胞需要雌激素生长。雌激素结合并激活这些细胞中的雌激素受体。他莫昔芬被代谢成化合物，其也与雌激素受体结合，但不激活它。由于这种竞争性的拮抗作用，他莫昔芬的作用就像锁中的钥匙一样，防止任何其他钥匙被插入，防止雌激素与其受体结合。因此乳腺癌细胞生长被阻断。
他莫昔芬由制药公司帝国化学工业公司（现为阿斯利康公司）发现，以商品名Nolvadex，Istubal和Valodex出售。然而，该药物在其专利期满之前已被其通用名“他莫昔芬”广泛引用。
在世界卫生组织的基本药物清单中，列出了基本卫生系统所需的最重要的药物。
Nolvadex副作用
他莫昔芬柠檬酸盐是一种选择性雌激素受体调节剂（SERM），以其最受欢迎的商品名Nolvadex最着名。一种非常强大而有效的SERM，Nolvadex被开发用于对付乳腺癌患者的雌激素;雌激素是这种病症的主要敌人之一。雌激素的问题是它与胸部区域的受体结合并导致癌症的发展; Nolvadex通过其天然作用模式防止雌激素在其位置上通过结合结合。当然，虽然这是SERM的原始意图，但它在性能提升圈中比其他地方更频繁地发现;我们指的是补充合成代谢类固醇的人。 Nolvadex真的不是用来直接提升性能的;然而，它被用作保护或恢复的手段。
当涉及到性能时，这种SERM有时用于个体补充芳香类固醇，以避免男子乳房发育症，或通常称为男性乳房肿大。当芳香酶过程发生时，这种致睾酮转化为雌激素，并且随着雌激素水平升高并附着于受体，它可导致男子乳腺发育。再次，该SERM将结合受体本身，从而防止雌激素结合并防止病症。然后我们有Nolvadex的恢复方面;在这种情况下，在合成代谢类固醇补充已经结束之后使用，以刺激由于使用合成代谢类固醇而被抑制的天然睾酮产生。在这种情况下，SERM将刺激垂体释放黄体激素（LH）和卵泡刺激激素（FSH），这反过来刺激睾丸使睾丸激素。没有LH和FSH，没有天然的睾酮生产; LH扮演主角。
虽然这是上述所有目的的真正有效的SERM，但可能存在Nolvadex副作用;这不能否认。即使如此，正如我们即将看到的那样，Nolvadex副作用大部分是非常轻微的，通常非常罕见，正确使用;事实上，严重的问题几乎闻所未闻。最常见的问题是非常长期的使用，如乳腺癌患者。对于性能增强器，这不会是一个问题，因为没有性能增强器将使用该SERM非常长的时间段。此外，尽管Nolvadex长期性的副作用是可能的，但仍然比处理乳腺癌更好。此外，据推测，Nolvadex报告的性能的副作用是不可能的;多年来存在的假设和神话，在这里我们将放下休息;事实上，这就是我们想要开始的地方。
不可能的Nolvadex副作用：
关于不可能的Nolvadex副作用，几十年来，许多性能增强剂都假设在循环使用时会抑制生长到一定程度;这个假设是不正确的。这个假设很简单他莫西芬柠檬酸盐是一种抗雌激素，并且由于需要一些雌激素来促进组织生长，其减少这种激素会使生长停滞一定程度。这是不正确的，只是基于Nolvadex不能降低雌激素水平。当然，可以发生的是抑制胰岛素样生长因子-1（IGF-1）的产生，这在生长方面是非常重要的。然而，它并没有那么干燥和干燥。虽然Nolvadex的副作用包括IGF-1减少，但大多数合成代谢类固醇的使用将显着增加，远远超出了SERM可能抑制的。还有一个问题有时会围绕抑制代谢或代谢功能而产生;然而，在提出这个问题的同时，也没有证据支持。
实际Nolvadex副作用：
虽然上述不是真正的关注，但是有一些实际的，但只有可能的Nolvadex副作用，首先值得一提的是认知能力的降低，但这是几乎严格的乳腺癌患者的关注，因为必要的长期使用SERM。有些甚至表明要长期使用性欲下降;这是有点讽刺意味，因为SERM通过LH和FSH刺激增加睾丸激素水平;然而，我们再次提到非常长期的使用。长期使用的最终关注是子宫内膜癌;一些研究表明，已经使用SERM五年以上的乳腺癌患者可能会开启子宫内膜癌的门;然而，没有关于短期使用的证据，因为这是一个子宫问题，这不是人的关切。
那么我们有性能提升，因为这将是我们最常找到这个SERM的地方，这个性质的Nolvadex副作用将是最想知道的。不幸的是，如果你正在寻找一个恐怖故事，你正在看错误的SERM或雌激素作战药物;如果您正在寻找恐怖故事，请尝试观察芳香酶抑制剂Cytadren。他莫昔芬柠檬酸盐通常由大多数性能增强的运动员非常耐受，包括男性和女性。最常见的Nolvadex副作用是毫无疑问的痤疮，但开始并不常见;这不是常见的，但它是最可能的。随着SERM的睾酮增加，睾酮水平的迅速增加可能导致一些突破;如果发生，通常会发生在背部，肩部或胸部，一旦调整，通常会消失;如果不是，它将在停产后。也有恶心，腹部绞痛和潮热的可能性;然而，这种副作用极其罕见，不会影响大多数人。这种影响是如此罕见，只有约5％的女性会出现恶心，只有约2％的男性，只有1％的女性会经历腹部绞痛，甚至更少的男性成为猎物。对于潮热，这是少数Nolvadex的副作用之一，可能是许多女性的问题，因为超过50％经常是猎物;然而，这与男人几乎闻所未闻。
正确使用Nolvadex避免副作用：
如果您要避免Nolvadex的副作用，如果您是乳腺癌患者，只需按照医师的指示使用SERM;这很简单。那么我们就会提高性能，在这种情况下，您将使用SERM，而不需要这样的指导，以及所有基于性能的项目都有自己的风险。当然，保持适量的剂量将始终为您服务，适当的剂量将根据使用的不同而有所不同。对于周期性男子乳房发育保护，大多数男性每天会发现10mg有效，如果有效;如果这不起作用，您可能需要一种芳香酶抑制剂。对于后期循环使用，您将需要一个更大的剂量，在四到六周的时间内逐渐减少。在大多数情况下，总共剂量为每天40mg，持续数周，然后是数周的一半，然后每天10mg剂量一天或两周是完美的。
他莫昔芬的好处
A.他莫昔芬减缓或停止已经存在于体内的癌细胞的生长。它有助于保持原来的乳腺癌的恢复，并有助于防止乳腺癌的新癌症。这也降低了这种疾病风险高的女性乳腺癌的风险。
B.他莫昔芬用于预防和治疗对雌激素受体（ER +）呈阳性的乳腺癌。它阻止了激素雌激素对癌细胞的影响，降低了乳腺癌生长的机会。它通常被称为“抗雌激素”。"
C.他莫昔芬在降低乳腺癌复发的风险方面非常有效。在已经患有乳腺癌的妇女中，他莫昔芬也降低了乳腺癌的乳腺癌风险（对侧）
D.对于绝经后妇女，使用他莫昔芬和芳香酶抑制剂如阿那曲唑（阿拉昔单抗），依西美坦（Aromasin）或来曲唑（Femara）的两阶段治疗可能比仅服用他莫昔芬更有效。
关于他莫昔芬Nolvadex的真相
Nolvadex降低雌激素水平是不正确的：相反，它阻止雌激素受体的雌激素受体，而在作为拮抗剂的那些组织中，雌激素阻碍雌激素的作用。
Nolvadex减少收益的说法不应该太重视。事实是，任何数量的健美运动员在使用Nolvadex时取得了很大的成就。
减少收益的信念似乎源于事实，科学文献报道了使用Nolvadex的IGF-1（使用合成代谢类固醇的个体尚未研究的个体）略有减少。
因此，丹·杜尚（Dan Duchaine）报道，它可以减少IGF-1，从而减少增益。但是，如果这种影响存在，那么由于许多人所取得的巨大成就，也没有人注意到Clomid有这样的事情，而且具有相同的活动形式，所以这一点也是非常小的。
Nolvadex会减少保水的事实可能导致用户同意减肥，因为体重增加较少，从而加强了偏见。
他莫昔芬应用：
Nolvadex是药物他莫昔芬柠檬酸盐的商品名，它是一种非甾体药物，具有很强的抗雌激素特性。该药物在技术上是雌激素激动剂/拮抗剂，其竞争性地结合各种靶组织中的雌激素受体。由于他莫昔芬分子与此受体结合，雌激素被阻止发挥任何作用，并获得抗雌激素作用。由于许多形式的乳腺癌对雌激素有反应，所以柠檬酸他莫昔芬阻断其在这些细胞中的作用的能力被证明是非常有效的治疗方法。它也被成功地用作预防措施，由具有极高家族倾向的乳腺癌患者采取。虽然Nolvadex对雌激素有效，但并不是我们最强的补救方法。我们现在有药物Arimidex，Femara和Aromasin可用于我们，这显着防止了雌激素的制造。改变女性体内雌激素的作用可引起不适，因此抗雌激素在绝经期使用时最为耐受。由于Nolvadex相对比较温和，它更广泛的应用，通常是第一个治疗方案。
Nolvadex是肝脏中的雌激素激动剂，能够激活雌激素受体并模仿这种性激素在身体的这个区域的作用。因此，与雌激素一样，它可以对HDL（良好）胆固醇值具有明显的积极影响。他莫昔芬目前用于治疗绝经前和绝经后妇女的早期和晚期ER +（雌激素受体阳性）乳腺癌。此外，它是男性乳腺癌最常见的激素治疗。它也被FDA批准用于预防高发生疾病风险的妇女的乳腺癌。已被进一步批准减少对侧（乳腺癌）。
规范：
女性三苯氧胺的Nolvadex剂量用于脂肪切割的柠檬酸盐减肥类固醇
他莫昔芬柠檬酸盐
别名：Nolvadex; TAM，他莫昔芬
cas no：54965-24-1
mf：c26h29no
mw：371.51
纯度：99％
熔点：140-144℃; Cdeg;C
沸点：482.3℃，760mmHg mmHg mmHg
结构体：
Einecs No：234-118-0
标准：企业标准
类别：合成代谢雄激素类固醇
外观：白色粉末。
储存：阴影，密闭保存
用途：用于抗雌激素诱导剂，功能失调性子宫出血，多囊卵巢，月经失调和药物性闭经等妇科疾病的对象，被用作乳腺癌的一线防御。
他莫昔芬COA评论：
TES测试 | 分析标准 | 结果 |
特点 | 白色结晶性粉末 | 符合 |
化验 | 99 ~ 101.0% | 99.51% |
干燥失重 | ≤0.5％0.5％0.5% | 0.24% |
鉴定 | 红外线，紫外线 | 符合 |
炽灼残渣 | ≤0.2％0.2％0.2% | 0.06% |
铁 | ≤0.005％005％005% | 0.0016% |
重金属 | ≤0.001％001％001% | 0.0006% |
相关物质 | 总计：≤1.0％1.0％1.0% | 0.37% |
Individual：≤0le; 0le;0个体：≤0.5％0.5％0.5%.5% | 0.17% | |
E-异构体 | ≤0.3％0.3％0.3% | 0.20% |
有机挥发性杂质 | 符合 | 符合 |
结论 | 该批次符合USP 30。 | |
包装和交货：非常：very:
我们有专业的团队包装和装运。特殊方式一次运送100克到100公斤的粉末到你的国家。可以安排快速和谨慎的货物通关保证。
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十多年来，所有粉末均由厂家直接供应。
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澳大利亚，日本，韩国等许多国家，每月超过3000t。
专业团队专门为包装和出货，盯着24小时跟踪代码
通过保证。 100％通过英国，挪威，波兰，西班牙，美国，加拿大，巴西; 98％通过
德国，俄罗斯，澳大利亚，新西兰。
4.大多数粉末都有库存，可收取样品，可在24小时内出货。
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| Model NO. | 10540-29-1 |
| Customized | Non-Customized |
| Suitable for | Adult |
| Purity | >99% |
| Appearance | White Crystalline Powder. |
| Alias | Nolvadex; Tam, Tamoxifen Citrat |
| Specification | GMP, SGS, ISO, KOSHER |
| HS Code | 6809900000 |
| Powder | Yes |
| Certification | GMP, ISO 9001, USP, BP |
| State | Solid |
| Product Name | Nolvadex |
| Usage | It' s Used to Anti-Estrogen Fertility Inducey Induce |
| Trademark | WHSM |
| Origin | China |
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Oral Anti Estrogen Tamoxifen Citrate / Nolvadex For Breast Cancer Treatment CAS 10540-29-1
1. Antitumor drugs raw material, suitable for breast cancer.It is not correct that Nolvadex reduces levels of estrogen: rather, it blocks estrogen from estrogen receptors and, in those tissues where it is an antagonist, causes the receptor to do nothing. Nolvadex is not an anabolic steroid but is used to manage side effects from steroids.
2. Tamoxifen is also used to treat breast cancer in women after they have finished early treatment. Early treatment can include surgery, radiation, and chemotherapy. Tamoxifen may keep the cancer from spreading to other parts of the body. It may reduce the chance of getting a new breast cancer.
3. Tamoxifen, an anticancer drug, is given to treat breast cancer in women and men.
Clomid vs nolvadex cycle reviews
Nolvadex and Clomid are two of the most popular Selective Estrogen Receptor Modulators (SERMs) in the world and part of the supplemental plan for many performance enhancing athletes. In many ways Nolvadex and Clomid are identical; in-fact, the same results can be obtained with either form assuming dosing is applied to match depending on the one you use. Without question the most common use of Nolvadex and Clomid is during what is known as Post Cycle Therapy (PCT) the period of time in-which an anabolic steroid cycle comes to an end and the recovery process begins. While the PCT period is a common points of use for these very effective SERMs some will alsosupplement during the actual anabolic steroid cycle itself in-order to combat possible side-effects such as Gynecomastia. Nolvadex and Clomid are both useful for on cycle Gynecomastia prevention but they will not equal the power of other options and are typically best served in a PCT role.
The Power of Nolvadex and Clomid:
For years many have argued that Nolvadex is the better SERM and far more effective than Clomid but this is a bit of an inaccurate statement. It is true, on a milligram for milligram basis Nolva, as it is commonly known is stronger than Clomid; 1mg of Nolvadex carries more potency than 1mg of Clomid. With that in mind if we equal the dosing, meaning, we increase the dosing of Clomid to match the potency of Nolva on a per milligram basis we largely have the same effect, the same results; those who typically do not like Clomid, especially during PCT usually are simply not taking enough.
Nolvadex and Clomid for PCT:
The purpose of PCT is simple and twofold; to stimulate natural testosterone production that has been suppressed due to the use of anabolic steroids and to simply normalize the body in-order to remain healthy. Of course, most are also concerned with hanging onto the gains they made from their performance cycle but effectively achieving the two previously mentioned factors will promote just that and in a positive fashion.
Implementing Nolvadex Post Cycle Therapy:
We do not simply and arbitrarily end our cycle of anabolic steroids and start our post cycle recovery; you must have an understanding of the steroids you were using in order to determine timing and this is very important. If you begin your Nolvadex post cycle plan too soon and you still have a lot of suppressive anabolic steroids in your system the whole recovery process will be a waste.
If your cycle ends with short ester anabolic steroids you may start your recovery process 2-3 days after your last injection; whether you are going to include hCG or not you will still start 2-3 days after the anabolic steroid cycle ends. If however your cycle ends with any long ester based steroids things will change; in this instance if you are going to include hCG into your Nolvadex post cycle plan you will begin hCG use ten days after your last steroidal injection; if your cycle ended with very long ester gear such as Deca-Durabolin it might be wise to wait a full two weeks. If your cycle ends with long ester steroids and you are not including hCG you will need to wait 2 weeks before Nolvadex post cycle therapy begins with 3 weeks being optimal if steroids such as Deca-Durabolin were being used at the end of the cycle.
What is nolvadex anti estrogen steroids?
Tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, 4-hydroxytamoxifen. In other tissues such as theendometrium, it behaves as an agonist, and thus may be characterized as a mixed agonist/antagonist. Tamoxifen is the usual endocrine(anti-estrogen) therapy for hormone receptor-positive breast cancer in pre-menopausal women, and is also a standard in post-menopausal women although aromatase inhibitors are also frequently used in that setting.
Some breast cancer cells require estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen is metabolized into compounds that also bind to the estrogen receptor but do not activate it. Because of this competitive antagonism, tamoxifen acts like a key broken off in the lock that prevents any other key from being inserted, preventing estrogen from binding to its receptor. Hence breast cancer cell growth is blocked.
Tamoxifen was discovered by pharmaceutical company Imperial Chemical Industries(now AstraZeneca) and is sold under the trade names Nolvadex,Istubal, and Valodex. However, the drug has been widely referred to by its generic name 'tamoxifen', even before its patent expiration.expiration.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.
Nolvadex Side Effects
Tamoxifen Citrate is a Selective Estrogen Receptor Modulator (SERM) best known by its most popular trade name Nolvadex. An extremely powerful and effective SERM, Nolvadex was developed to fight estrogen in breast cancer patients; estrogen being one of the primary enemies to such a condition. The problem with estrogen is it binds to the receptors in the chest region and causes the cancer to thrive; Nolvadex by its natural mode of action prevents the estrogen from binding by binding in its place. Of course, while this was the SERM's original intent, it is found in performance enhancing circles far more often than anywhere else; we're referring to those who supplementwith anabolic steroids. Nolvadex really isn't used to promote performance directly; however, it's used as a means of protection or recovery.
When it comes to performance, this SERM is sometimes used while the individual is supplementing with aromatizing steroids in an effort to stave off gynecomastia, or what's often referred to as male-breast enlargement. When the aromatase process occurs, this causestestosterone to convert into estrogen, and as estrogen levels increase and attach to the receptors it can lead to gynecomastia. Once again, this SERM will bind to the receptors itself, thereby preventing the estrogen from binding and preventing the condition. Then we have the recovery aspect of Nolvadex; in this case, it is used after anabolic steroid supplementation has come to an end in an effort to stimulate natural testosterone production which has been suppressed due to the use of anabolic steroids. In this case, the SERM will stimulate the pituitary to release Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH), which in-turn stimulates the testicles to make testosterone. Without LH and FSH, there is no natural testosterone production; LH playing the primary role.
While this is a truly effective SERM for all the purposes mentioned above, there are possible Nolvadex side effects; this cannot be denied. Even so, as we will soon see, Nolvadex side effects are for the most part extremely mild and often very rare with proper use; in-fact, serious problems are almost unheard of. Where problems most commonly occur is with extremely long-term use, such as for a breast cancer patient. For the performance enhancer, this won't be an issue as no performance enhancer will be using this SERM for extremely long periods of time. Further, while Nolvadex side effects of a long-term nature are possible, they are still better than dealing with breast cancer. Moreover, there are also supposed Nolvadex side effects of a reported performance nature that are impossible; assumptions and myths that have existed for years, and it is here we will lay those to rest; in-fact, that's where we want to start.
Impossible Nolvadex Side Effects:
When it comes to the impossible Nolvadex side effects, for decades many performance enhancers have assumed on-cycle use will inhibit growth to a degree; this assumption would be incorrect. The assumption is simple; Tamoxifen Citrate is an anti-estrogen, and as some estrogen is needed to promote tissue growth its reduction of this hormone will stagnate growth to a degree. This is incorrect simply on the basis that Nolvadex does not reduce estrogen levels. Of course, what can occur is a suppression of Insulin-Like Growth Factor-1 (IGF-1) production, and this is extremely important in-regards to growth; however, it's not so cut and dry. While Nolvadex side effects due include an IGF-1 reduction, the use of most anabolic steroids will dramatically increase it far beyond what this SERM might suppress. There is also an issue that is sometimes brought up revolving around a suppressed metabolism or metabolic function; however, while the issue has been brought up there is no evidence to support it.
Actual Nolvadex Side Effects:
While the above are of no true concern, there are a few actual yet only possible Nolvadex side effects, and the first worthy of mention is a reduction in cognitive abilities, but this is something that is almost strictly a breast cancer patient concern due to the necessary long-term use of the SERM. Some have even shown to have a reduction in libido with long-term use; this is somewhat ironic since the SERM increasestestosterone levels via LH and FSH stimulation; however, we're once again referring to extremely long-term use. The final concern with long-term use is endometrial cancer; some studies have shown breast cancer patients who have used the SERM for five or more years may open the door to endometrial cancer; however, there's no evidence in-regard to short-term use, and as this is a uterus issue it is not a concern for men.
Then we have performance enhancement, and as this will be where we'll find this SERM most commonly, Nolvadex side effects of this nature will be what most want to know about. Unfortunately, if you're looking for a horror story, you're looking at the wrong SERM or estrogenic combatant medication; if you're looking for horror stories, try looking at the Aromatase Inhibitor Cytadren. Tamoxifen Citrate is normally very well-tolerated by most performance enhancing athletes, and this includes men and women. The most common Nolvadex side effect is without question acne, but it's not that common to begin with; it's not that common but it's the most probable. With the testosterone increasing nature of this SERM, the quick increase in testosterone levels can cause some breakouts; if it occurs, it will normally occur on the back, shoulders or chest, and normally fades away once you adjust; if not it will after discontinuation. There is also the possibility of nausea, abdominal cramping and hot flashes; however, such side effects are extremely rare and will not affect most people. Such effects are so rare, only about 5% of women will experience nausea, only about 2% of men, and only 1% of women will experience abdominal cramping with even less men falling prey. As for hot flashes, this is one of the few Nolvadex side effects that can be a problem for numerous women, as more than 50% often fall prey; however, it's virtually unheard of with men.
Proper Use of Nolvadex to Avoid Side Effects:
If you're to avoid Nolvadex side effects, if you're a breast cancer patient simply use the SERM as directed by your physician; that's fairly simple. Then we have performance enhancement, and in this case, you'll be using the SERM without such guidance and as with all performance based items at your own risk. Of course, keeping the dosing proper will always serve you best, and proper dosing will vary depending on the point of use. For on-cycle gynecomastia protection, most men will find 10mg per day to be effective if it's going to be effective; if this doesn't work, you'll probably need an Aromatase Inhibitor. As for post cycle use, you will need a larger dosing that tapers down over the course of four to six weeks. In most cases, a total dosing of 40mg per day for a couple weeks, followed by half that amount for a couple weeks and then a 10mg dosing per day for a week or two is perfect.
Benefits of Tamoxifen
A. Tamoxifen slows or stops the growth of cancer cells that are already present in the body. It helps keep the original breast cancer from coming back and helps prevent new cancer in the opposite breast. It also reduces the risk of breast cancer in women who have a high risk for this disease.
B. Tamoxifen is used to prevent and treat breast cancers that test positive for estrogen receptors (ER+). It blocks the effects that the hormone estrogen has on cancer cells and lowers the chance that breast cancer will grow. It is often called an 'anti-estrogen.'ogen.""
C. Tamoxifen is highly effective in lowering the risk of breast cancer recurrence. In women who have already had breast cancer, tamoxifen also lowers the risk of breast cancer in the opposite breast (contralateral)
D. For postmenopausal women, a two-stage treatment using tamoxifen and then an aromatase inhibitor, such as anastrozole (Arimidex), exemestane (Aromasin), or letrozole (Femara) may work better than only taking tamoxifen.
The truth about Tamoxifen Nolvadex
It is not correct that Nolvadex reduces levels of estrogen: rather, it blocks estrogen from estrogen receptors and, in those tissues where it is an antagonist, causes the receptor to do nothing.
The claim that Nolvadex reduces gains should not be taken too seriously. The fact is that any number of bodybuilders have made excellent gains while using Nolvadex.
The belief that it reduces gains seems to stem from the fact that the scientific literature reports a slight reduction in IGF-1 (individuals using anabolic steroids were not studied though) from use of Nolvadex.
Thus, Dan Duchaine reported that it reduces IGF-1 and therefore reduces gains. However, if this effect exists at all, it must be very minor, due to the excellent gains that many have made, and from the fact that no one has noticed any such thing from Clomid, which has the same activity profile.
The fact that Nolvadex will reduce water retention may result in the user agreeing that gains are less, since weight gain is less, thus reinforcing the bias.
Tamoxifen Application:
Nolvadex is the trade name for the drug tamoxifen citrate, it is a non-steroidal agent that demonstrates potent anti-estrogenic properties. The drug is technically an estrogen agonist/antagonist, which competitively binds to estrogen receptors in various target tissues. With the tamoxifen molecule bound to this receptor, estrogen is blocked from exerting any action, and an anti-estrogenic effect is achieved. Since many forms of breast cancer are responsive to estrogen, the ability of tamoxifen citrate to block its action in such cells has proven to be a very effective treatment. It is also utilized successfully as a preventative measure, taken by people with an extremely high familial tendency for breast cancer. While Nolvadex is effective against estrogen, it is not our strongest available remedy. We now have the drugs Arimidex, Femara, and Aromasin available to us, which notably prevents estrogen from being manufactured in the first place. Altering the effect of estrogen in the female body can cause a level of discomfort, so anti-estrogens are most bearable when used after the point of menopause. Since Nolvadex is milder in comparison, it is more widely applicable and usually the first treatment option.
Nolvadex is an estrogen agonist in the liver, capable of activating the estrogen receptor and mimicking the actions of this sex hormone in this region of the body. As such it can have a markedly positive impact on HDL (good) cholesterol values, as does estrogen. Tamoxifen is currently used for the treatment of both early and advanced ER+ (estrogen receptor positive) breast cancer in pre- and post-menopausal women. Additionally, it is the most common hormone treatment for male breast cancer. It is also approved by the FDA for the prevention of breast cancer in women at high risk of developing the disease. It has been further approved for the reduction of contralateral (in the opposite breast) cancer.
Specification:
Nolvadex dosage for female tamoxifen Citrate weight loss steroids for fat cutting
Tamoxifen Citrate
Alias: Nolvadex; TAM,Tamoxifen citrat,
CAS No: 54965-24-1
MF: C26H29NO
MW: 371.51
Purity: 99%
Melting Point: 140-144°Cdeg;Cdeg;C
Boiling point: 482.3°C at 760 mmHg mmHg mmHg
Structure:
Einecs No: 234-118-0
Standard: Enterprise Standard
Category: Anabolic Androgenic Steroid
Appearance: White powder.
Storage: Shading, confined preservation
Usage: It's used to anti-estrogen fertility inducer, the objects in dysfunctional uterine bleeding, polycystic ovary, menstrual disorders and drug-induced amenorrhea and other gynecologic diseases;It is used as a first line defense against breast cancer.
Tamoxifen COA reviews:
Testest | Analysis Standard | Results |
Characteristics | White crystalline powder | conforms |
Assay | 99 ~ 101.0% | 99.51% |
Loss on drying | ≤0.5%0.5%0.5% | 0.24% |
Identification | IR,UV conform | conforms |
Residue on ignition | ≤0.2%0.2%0.2% | 0.06% |
Iron | ≤0.005%005%005% | 0.0016% |
Heavy metals | ≤0.001%001%001% | 0.0006% |
Related substances | Total:≤1.0%1.0%1.0% | 0.37% |
Individual:≤0le;0le;0Individual:≤0.5%0.5%0.5%.5% | 0.17% | |
E-isomer | ≤0.3%0.3%0.3% | 0.20% |
Organic volatile impurities | conform | conform |
Conclusion | This batch is complies with USP 30. | |
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