口服抗雌激素他莫昔芬柠檬酸盐/乳腺癌乳腺癌治疗CAS 10540-29-1

快速详细：

描述：

Nolvadex（他莫昔芬柠檬酸盐）与Clomid非常相似，在所有组织中表现相同，并且是与Clomid相同类型的混合雌激素激动剂/拮抗剂。两个分子的结构也非常相似。 Nolvadex降低雌激素水平是不正确的：相反，它阻止雌激素受体的雌激素受体，而在那些作为拮抗剂的组织中，它会导致受体不起作用。
Nolvadex会减少保水的事实可能导致用户同意收益较少，因为体重增加较少，从而加强了偏见。

关于他莫昔芬Nolvadex的真相
Nolvadex降低雌激素水平是不正确的：相反，它阻止雌激素受体的雌激素受体，而在作为拮抗剂的那些组织中，雌激素阻碍雌激素的作用。
Nolvadex减少收益的说法不应该太重视。事实是，任何数量的健美运动员在使用Nolvadex时取得了很大的成就。
Nolvadex会减少保水的事实可能导致用户同意减肥，因为体重增加较少，从而加强了偏见。

他莫昔芬应用：

Nolvadex是药物他莫昔芬柠檬酸盐的商品名，它是一种非甾体药物，具有很强的抗雌激素特性。该药物在技术上是雌激素激动剂/拮抗剂，其竞争性地结合各种靶组织中的雌激素受体。由于他莫昔芬分子与此受体结合，雌激素被阻止发挥任何作用，并获得抗雌激素作用。由于许多形式的乳腺癌对雌激素有反应，所以柠檬酸他莫昔芬阻断其在这些细胞中的作用的能力被证明是非常有效的治疗方法。它也被成功地用作预防措施，由具有极高家族倾向的乳腺癌患者采取。虽然Nolvadex对雌激素有效，但并不是我们最强的补救方法。我们现在有药物Arimidex，Femara和Aromasin可用于我们，这显着防止了雌激素的制造。改变女性体内雌激素的作用可引起不适，因此抗雌激素在绝经期使用时最为耐受。由于Nolvadex相对比较温和，它更广泛的应用，通常是第一个治疗方案。

Nolvadex是肝脏中的雌激素激动剂，能够激活雌激素受体并模仿这种性激素在身体的这个区域的作用。因此，与雌激素一样，它可以对HDL（良好）胆固醇值具有明显的积极影响。他莫昔芬目前用于治疗绝经前和绝经后妇女的早期和晚期ER +（雌激素受体阳性）乳腺癌。此外，它是男性乳腺癌最常见的激素治疗。它也被FDA批准用于预防高发生疾病风险的妇女的乳腺癌。已被进一步批准减少对侧（乳腺癌）。

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Oral Anti Estrogen Tamoxifen Citrate / Nolvadex For Breast Cancer Treatment CAS 10540-29-1

Quick Detail:

Description:

Nolvadex (tamoxifen citrate) is very comparable to Clomid, behaves in the same manner in all tissues, and is a mixed estrogen agonist/antagonist of the same type as Clomid. The two molecules are also very similar in structure. It is not correct that Nolvadex reduces levels of estrogen: rather, it blocks estrogen from estrogen receptors and, in those tissues where it is an antagonist, causes the receptor to do nothing.
The fact that Nolvadex will reduce water retention may result in the user agreeing that gains are less, since weight gain is less, thus reinforcing the bias.,

The truth about Tamoxifen Nolvadex
It is not correct that Nolvadex reduces levels of estrogen: rather, it blocks estrogen from estrogen receptors and, in those tissues where it is an antagonist, causes the receptor to do nothing.
The claim that Nolvadex reduces gains should not be taken too seriously. The fact is that any number of bodybuilders have made excellent gains while using Nolvadex.
The fact that Nolvadex will reduce water retention may result in the user agreeing that gains are less, since weight gain is less, thus reinforcing the bias.

Tamoxifen Application:

Nolvadex is the trade name for the drug tamoxifen citrate, it is a non-steroidal agent that demonstrates potent anti-estrogenic properties. The drug is technically an estrogen agonist/antagonist, which competitively binds to estrogen receptors in various target tissues. With the tamoxifen molecule bound to this receptor, estrogen is blocked from exerting any action, and an anti-estrogenic effect is achieved. Since many forms of breast cancer are responsive to estrogen, the ability of tamoxifen citrate to block its action in such cells has proven to be a very effective treatment. It is also utilized successfully as a preventative measure, taken by people with an extremely high familial tendency for breast cancer. While Nolvadex is effective against estrogen, it is not our strongest available remedy. We now have the drugs Arimidex, Femara, and Aromasin available to us, which notably prevents estrogen from being manufactured in the first place. Altering the effect of estrogen in the female body can cause a level of discomfort, so anti-estrogens are most bearable when used after the point of menopause. Since Nolvadex is milder in comparison, it is more widely applicable and usually the first treatment option.

Nolvadex is an estrogen agonist in the liver, capable of activating the estrogen receptor and mimicking the actions of this sex hormone in this region of the body. As such it can have a markedly positive impact on HDL (good) cholesterol values, as does estrogen. Tamoxifen is currently used for the treatment of both early and advanced ER+ (estrogen receptor positive) breast cancer in pre- and post-menopausal women. Additionally, it is the most common hormone treatment for male breast cancer. It is also approved by the FDA for the prevention of breast cancer in women at high risk of developing the disease. It has been further approved for the reduction of contralateral (in the opposite breast) cancer.

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