制药原料盐酸西酞普兰CAS; 536-43-6
快速细节;
名称;盐酸德乐宁
生物学描述;钠通道阻滞剂。 HSP90伴侣蛋白抑制剂。在体内显示局部麻醉效果。口腔活跃
化学名称; 1-（4-丁氧基苯基）-3-哌啶-1-基丙-1-酮盐酸盐
CAS; 536-43-6
分子量325.87
式; C18H27NO2.HCl
溶解性概述;可溶于水至10mM，DMSO中至25mM，乙醇至100mM
产品规格：

Decriptions;
盐酸德乐宁是Dyclonine的盐酸盐，是具有局部麻醉作用的未分类化合物。达克罗宁可逆地结合神经元膜上的活化钠通道，从而降低神经元膜对钠离子的通透性，导致激发阈值增加。这可逆地稳定膜并抑制去极化，导致传播的动作电位和随后的传导阻滞的失败。这导致身体的局部区域中的瞬态和可逆的感觉丧失。
用户;
牙科手术 - 局部麻醉：0.5％溶液作为喷雾或漱口
局部麻醉：剂量变化，取决于麻醉区域，组织血管，个体耐受性和麻醉技术
局部麻醉：4至20 mL 1％喷雾主要用于可渗透的粘膜;最大剂量300mg;单次剂量MAX 200 mg
局部麻醉：将0.5％溶液主要用作湿敷或作为外阴切开术或围产期伤口的喷雾剂
局部麻醉：应用0.5％溶液浸润的棉或海绵的标本，按照直肠手术方式对术后伤口
咽喉疼痛：根据需要，每2小时缓慢溶解2至3毫克锭剂
咽喉疼痛：4次喷雾0.1％喷雾，带燕子;可用于漱口或冲洗受影响的区域15秒，并根据需要每天吐出6次
咽部反射发现：0.5％溶液作为漱口水或漱口
口炎：5〜15 mL 0.5％溶液，口服食管食管;作为冲洗或拭子应用于口腔发炎或溃疡的粘膜

Pharmaceutical Raw Materials Dyclonine Hydrochloride CAS; 536-43-6
Quick detail;
Name;Dyclonine hydrochloride
Biology description;Sodium channel blocker. HSP90 chaperone protein inhibitor. Shows local anesthetic effects in vivo. Orally active.
Chemical Name;1-(4-Butoxyphenyl)-3-piperidin-1-ylpropan-1-one hydrochloride
CAS; 536-43-6
Molecular weight; 325.87
Formula; C18H27NO2.HCl
Solubility Overview; Soluble in water to 10 mM, in DMSO to 25 mM and in ethanol to 100 mM
Specifications:

Decriptions;
Dyclonine Hydrochloride is the hydrochloride salt of Dyclonine, an unclassified compound with local anesthetic effect. Dyclonine reversibly binds to activated sodium channels on the neuronal membrane, thereby decreasing the neuronal membrane's permeability to sodium ions, leading to an increased threshold for excitation. This reversibly stabilizes the membrane and inhibits depolarization, leading to the failure of a propagated action potential and subsequent conduction blockade. This results in a transient and reversible loss of sensation in a localized area of the body.
User;
Dental procedure - Local anesthesia: 0.5% solution ORALLY as a spray or gargle
Local anesthesia: dosage varies and depends upon the area to be anesthetized, vascularity of the tissues, individual tolerance, and the technique of anesthesia
Local anesthesia: 4 to 20 mL of 1% spray TOPICALLY to accesible mucous membranes; MAX dose 300 mg; single dose MAX 200 mg
Local anesthesia: apply 0.5% solution TOPICALLY as wet compresses or as a spray to episiotomy or perineorrhaphy wounds
Local anesthesia: apply pledgets of cotton or sponges moistened with 0.5% solution TOPICALLY to postoperative wounds following proctology procedures
Pain in throat: one 2 to 3 mg lozenge ORALLY dissolved in mouth slowly every 2 h as needed
Pain in throat: 4 sprays of 0.1% spray ORALLY with swallow; may be used as gargle or rinse on the affected area for 15 sec and spit out 6 times a day as needed
Pharyngeal gag reflex finding: 0.5% solution ORALLY as mouthwash or gargle
Stomatitis: 5 to 15 mL of 0.5% solution ORALLY with swallow for lesions of the esophagus; as a rinse or swab applied to inflamed or ulcerated mucous membranes of the mouth