药用原料盐酸左布比卡因局部麻醉
快速细节;
化学名称：盐酸左布比卡因
同位素;布比卡因hcl;（ - ） - 布比卡因;左旋咪唑盐; l - （ - ） - 布比卡因; timtec-bb sbb001337;左布比卡因hcl;（ - ） - 布比卡因;（ - ） - 布比卡因
CBNumber：CB3408801
CAS; 27262-48-2
分子式; C18H29ClN2O
测定;≥98％（hplc）plc）PLC)
光学活性;'α'/ D -10至-14°，c = 1.0在H 2 O 1.0中的H 2 O 1.0 in H2O
产品规格：

描述;
左布比卡因盐酸盐是左布比卡因的盐酸盐，具有麻醉性质的酰胺衍生物。左布比卡因可逆地结合电压门控钠通道以调节离子通量并防止神经冲动的起始和传递（稳定神经元膜），从而导致镇痛和麻醉。与消旋布比卡因相比，左布比卡因与较少的血管舒张有关，并且具有较长的作用时间。
布比卡因分子是外消旋化合物。左布比卡因是布比卡因的S-对映异构体，被认为具有比R-对映异构体更低的心脏毒性潜力。左布比卡因的药代动力学参数与布比卡因相似。
应用;
左布比卡因已经在手术麻醉和疼痛管理方面进行了研究。可用于局部浸润，硬膜外，鞘内和周围神经阻滞。对于硬膜外镇痛，可给予可乐定。左布比卡因和布比卡因的双盲比较显示其麻醉效果相似。
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Phamaceutical raw materials Levobupivacaine Hydrochloride for local anaesthetic
Quick detail;
Chemical Name:Levobupivacaine hydrochloride
Synonyms;BUPIVACAINE HCL;(S)-Bupivacaine;LEVAMISOLHCLSALT;L-(-)-Bupivacaine;TIMTEC-BB SBB001337;LEVOBUPIVACAINE HCL;(S)-(-)-Bupivacaine;(S)-(-)-BUPIVACAINE HCL
CBNumber:CB3408801
CAS;27262-48-2
Molecular Formula;C18H29ClN2O
assay;≥98% (HPLC)PLC)PLC)
optical activity;[α]/D -10 to -14°, c = 1.0 in H2O 1.0 in H2O 1.0 in H2O
Specifications:

Description;
Levobupivacaine Hydrochloride is the hydrochloride salt of levobupivacaine, an amide derivative with anesthetic property. Levobupivacaine reversibly binds voltage-gated sodium channels to modulate ionic flux and prevent the initiation and transmission of nerve impulses (stabilizing neuronal membrane), thereby resulting in analgesia and anesthesia. In comparison with racemic bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action.
The bupivacaine molecule is a racemic compound. Levobupivacaine is the S-enantiomer of bupivacaine and is thought to have less cardiotoxic potential than the R-enantiomer. The pharmacokinetic parameters of levobupivacaine are similar to those of bupivacaine.
Application;
Levobupivacaine has been studied in surgical anaesthesia and for pain management. It can be used for local infiltration, epidural, intrathecal and peripheral nerve blocks. For epidural analgesia it can be given with clonidine. Double-blind comparisons of levobupivacaine and bupivacaine show that their anaesthetic effects are similar.
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