2/5/10 mg /瓶Melanotan-1肽Melanotan II Melanotan-2

美拉诺坦-1,2mg /小瓶，5mg /小瓶，10mg /小瓶
cas：75921-69-6
mf：c78h111n21o19
mw：1646.85
链：AC-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-PRO-Val-NH 2
外观：无菌过滤白色冻干（冷冻干燥）粉末
纯度（通过HPLC）：> 99.00％〜99.90％
总杂质（通过HPLC）：1.00％〜0.05％
单一杂质（通过HPLC）：<0.50％〜0.08％
产地：中国（内地）
储存条件：Aviod shunshine和保持塞住

规范：

描述：

美拉诺坦1（也称为Afamelanotide）是肽激素的合成肽变体，称为α-黑色素细胞刺激激素或MSH，其在体内天然产生并负责刺激黑素生成，皮肤色素沉着的肽过程。 α-MSH在发挥其作用的过程中激活某些黑皮质素受体。事实上，MSH还通过这些黑皮质素受体对脂质代谢，食欲和性欲有强烈的影响。因此，Melanotan-1的日晒皮肤晒黑效果。虽然Melanotan 2和PT-141已被长期研究作为治疗性功能障碍的潜在疗法，但是Melanotan-1已被广泛研究用于防止由于其黑素生成刺激性质而对来自阳光的紫外线辐射的有害影响。
Melanotan-1和Melanotan 2都是趋向于诱导皮肤晒黑的肽激素α-黑素细胞刺激激素（α-MSH）的类似物。与Melanotan 1不同，Melanotan 2已显示具有春药属性，增加性欲的额外效果。美拉诺坦-1是黑皮质素受体的非选择性激动剂（MC1R，MC3-5R）。作为α-MSH的类似物，其作用机制是天然哺乳动物鞣制过程的仿生学

美拉诺坦的发展1
最初产生的美拉诺坦1肽鞣制类似物可以归功于亚利桑那大学。在旨在开发针对皮肤癌的防御的研究过程中，重点在于开发刺激天然黑素生成或皮肤中黑色素的自然产生的方法，而不直接暴露于阳光中的潜在有害的紫外线辐射。最初，亚利桑那大学的研究人员试图直接施用天然存在的激素α-MSH，以便得到所需的结果。尽管该策略表现出有希望的结果，但确定了天然存在的MSH具有非常短的半衰期以作为治疗性补救的实际用途。然而，从MSH施用收集的阳性结果鼓励对Melanotan 1的发展的进一步研究，其显示出类似的效果，同时具有用于功能性治疗应用的延长的半衰期。由Victor J.Hruby和Mac E.Hadley领导的研究人员发现了一种肽“Nle4，D-Phe7'-α-MSH”，其效力比天然α-MSH强大约1,000倍。他们将这种新的肽分子命名为“Melanotan”（以后称为Melanotan-1）。


Melanotan-1行动机制 - 它如何工作！
美拉诺坦产生其光保护作用，通过其激活MC1R对称为黑素细胞的黑色素产生细胞的触发“信号级联”。当美拉诺坦与皮肤表皮层中黑素细胞表面上的MC1R结合时，它开始一系列的作用和反应，导致黑素细胞有利于产生真黑素（光保护黑色/棕色色素）。初始结合激活MC1R，导致腺苷酸环化酶（AC）的活化和刺激环腺苷酸（cAMP）的产生。 cAMP反过来活化蛋白激酶A（PKA），导致cAMP应答元件结合（CREB）的磷酸化。磷酸化的CREB将结合到小神经炎相关转录因子（MITF）基因上的cAMP反应元件（CRE），导致MITF蛋白的合成。 MITF具有通过与其结合来激活几种基因的能力，包括MC1R基因和涉及黑素生成的基因。这导致黑素细胞内黑素生成酶的浓度增加。

美拉诺坦可以指两种单独的肽之一：Afamelanotide，最初以名称“Melanotan1”或“Melanotan I”开发用于皮肤鞣制，目前以植入形式试验的药物作为一系列轻度受影响的皮肤病症的预防性治疗，潜在的皮肤癌预防剂。


Melanotan II，一种最初作为皮肤鞣剂开发的药物，但随后被研究作为性功能障碍的潜在治疗。

美拉诺坦2（也称为美拉诺坦II）是在体内天然产生的肽激素的合成产生的变体，其刺激黑素生成，所述黑素生成是负责皮肤色素沉着的过程。这种肽激素，称为α-黑素细胞刺激激素或MSH，在发挥其作用的过程中激活某些黑皮质素受体。事实上，MSH还通过这些黑皮质素受体对脂质代谢，食欲和性欲有显着的影响。因此，除了促进皮肤晒黑之外，美拉诺坦2已经在研究中显示表现出食欲抑制剂，脂肪分解和性欲增强效果。美拉诺坦2已被广泛研究用于防止由于其黑素生成刺激性质而对来自日光的紫外线辐射的有害影响。

另外，已经将Melanotan 2和类似的合成产生的变体（称为PT-141）长期研究作为治疗性功能障碍的潜在疗法;特别是男性勃起功能障碍。


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我们公司有严格的质量保证和质量控制体系，所有的产品都符合USP标准以及企业内部控制标准。

其他肽：

2 / 5 / 10 mg / vial Melanotan-1 Peptide Melanotan II Melanotan-2

Melanotan-1, 2mg/vial, 5mg/vial, 10mg/vial
CAS: 75921-69-6
MF: C78H111N21O19
MW: 1646.85
Chain: AC-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-PRO-Val-NH2
Appearance: Sterile Filtered White lyophilized (freeze-dried) powder
Purity(by HPLC): ﹥99.00%~99.90%
Total Impurities(by HPLC): 1.00%~0.05%
Single Impurity(by HPLC): ﹤0.50%~0.08%
Origin: China (Mainland)
Storage conditions: Aviod shunshine and keeping stoppered

Specification:

Description:

Melanotan 1 (also referred to as Afamelanotide) is a synthetic peptide variant of a peptide hormone, called alpha-Melanocyte stimulating hormone or MSH that is naturally produced in the body and is responsible for stimulating melanogenesis, a peptide process for pigmentation of the skin. Alpha-MSH activates certain melanocortin receptors in the process of exerting its effects. Indeed, MSH also exerts potent influence over lipid metabolism, appetite, and sexual libido via these melanocortin receptors. As a result, Melanotan-1 sunless skin tanning effects. While Melanotan 2 and PT-141 have been studied at length as a potential remedies for the treatment of sexual dysfunction, Melanotan-1 has been researched extensively for use in protecting against the harmful effects of ultraviolet radiation from sunlight due to its melanogenesis-stimulating properties.
Both Melanotan-1 and Melanotan 2 are analogs of the peptide hormone alpha-melanocyte stimulating hormone (α-MSH) that tend to induce skin tanning. Unlike Melanotan 1, Melanotan 2 has been shown to have aphrodisiac properties, the additional effect of increasing libido. Melanotan-1 is a non selective agonist of the melanocortin receptors (MC1R,MC3-5R). As an analogue of α-MSH, its mechanism of action is biomimicry of the natural mammalian tanning process

The Development of Melanotan 1
The initial creation of the Melanotan 1 peptide tanning analogue can be credited to the University of Arizona. During the course of study aimed at developing a defense against skin cancer, focus was placed on developing a method of stimulating natural melanogenesis, or the natural production of melanin in the skin, without direct exposure to the potentially harmful ultraviolet radiation in sunlight. Initially, University of Arizona researchers attempted to directly administer the naturally occurring hormone alpha-MSH in order to elicit this desired result. Although this strategy exhibited promising results, it was determined that the naturally occurring MSH had a prohibitively short half-life to be of realistic use as a therapeutic remedy. However, the positive results gleaned from MSH administration encouraged further research into the development of Melanotan 1, which exhibits similar effects whilst possessing an extended half-life for functional therapeutic utilization. The researchers, headed by Victor J. Hruby and Mac E. Hadley, found a peptide, [Nle4, D-Phe7]-α-MSH, that was approximately 1,000 times more potent than natural α-MSH. They named this new peptide molecule 'Melanotan' (later Melanotan-1).


Melanotan-1 Mechanism of Action - How it Works!
Melanotan produces its photoprotective effects by triggering a 'signaling cascade' via its activation of the MC1R on melanin-producing cells known as melanocytes. Upon Melanotan binding with the MC1R on the surface of melanocytes in the epidermal layer of the skin, it begins a series of actions and reactions that result in melanocytes favoring the production of eumelanin (photoprotective black/brown pigment). The initial binding activates the MC1R leading to the activation of adenylate cyclase (AC) and stimulation of the production of cyclic adenosine monophosphate (cAMP). cAMP in turn activates protein kinase A (PKA) resulting in the phosphorylation of the cAMP response element-binding (CREB). Phosphorylated CREB will bind to the cAMP response element (CRE) on the microphthalmia-associated transcription factor (MITF) gene leading to the synthesis of the MITF protein. MITF has the ability to activate several genes by binding to them, including the MC1R gene and the genes involved in melanogenesis. This results in increased concentrations of the melanogenic enzymes within the melanocyte.

Melanotan may refer to one of two separate peptides : Afamelanotide, originally developed under the names 'Melanotan1' or 'Melanotan I' for skin tanning, a drug currently in trials in implant form as a prophylactic treatment for a series of light affected skin disorders and potential skin cancer preventative agent.


Melanotan II, a drug originally developed as a skin tanning agent, but subsequently investigated as a potential treatment for sexual dysfunction.

Melanotan 2 (also referred to as Melanotan II) is a synthetically produced variant of a peptide hormone naturally produced in the body that stimulates melanogenesis, a process responsible for pigmentation of the skin. This peptide hormone, called alpha-Melanocyte stimulating hormone or MSH, activates certain melanocortin receptors in the process of exerting its effects. Indeed, MSH also exerts potent influence over lipid metabolism, appetite, and sexual libido via these melanocortin receptors. As a result, Melanotan 2 has been shown in studies to exhibit appetite suppressant, lipolytic, and libido-enhancing effects in addition to promoting skin tanning. Melanotan 2 has been researched extensively for use in protecting against the harmful effects of ultraviolet radiation from sunlight due to its melanogenesis-stimulating properties.

Additionally, Melanotan 2 and a similar synthetically produced variant, known as PT-141, have been studied at length as a potential remedy for the treatment of sexual dysfunction; specifically, male erectile dysfunction.


Our Advantages:

Hubei Holy Biological Co., Ltd. has been developing and producing high quality products under stric GMP conditions. Quality control and quality assurance are given high priority in order to meet international pharmacopoeia specifications and special customer's requirements.
1. Method of Analysis for testing our materials are validated to give the re-producible results
2. All the analytical test procedures and manufacturing procedures are well documented and revision is undertaken as per specified protocol.
3. Trend analysis of purified water and final products are maintained.
4. Stability study is a very important area of quality assuance.

Our company has a strict QA&QC system and all of products are in line with the USP standard as well as enterprise internal control standard.

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