有效的药物级材料异维A酸治疗痤疮

产品详情：

异维甲酸同义词：13-cis-ra; 13-顺式 - 视黄酸; 13-ra;异亮氨酸异丝氨酸新维生素RO-4-3780
异维甲酸CAS：4759-48-2
异维A酸MF：C 20 H 28 O 2
异维甲酸MW：300.44
异维甲酸EINECS：225-296-0
异维A酸测定：99％
异维甲酸外观：橙色结晶粉末
异维A酸规格：USP
异维甲酸用途：作为类视黄醇，具有强而快的增殖抑制和分化皮肤腺细胞功能，对严重结节性囊性痤疮有效。胃肠道吸收更好，而局部用药无效。其他用于治疗无效严重痤疮，囊性痤疮，阴囊痤疮，红斑痤疮，鱼鳞癣，滤泡性角化病和毛发糠疹和其他皮肤病的药物也有一定的疗效。
异维A酸用于严重痤疮。抗皮肤角化不良症。用于治疗严重痤疮和其他疾病。

描述：

异维甲酸（INN）（词源和发音），也称为13-顺式视黄酸，是主要用于治疗囊性痤疮的口服药物。很少，它也用于预防某些皮肤癌（鳞状细胞癌），和用于治疗其他癌症。它用于治疗丑角型鱼鳞病，通常致命的皮肤病和鳞状鱼鳞病。它是类维生素A，意思是它与维生素A有关，并且在体内天然存在少量。其异构体，维A酸也是痤疮药。

异维A酸主要用于治疗严重的痤疮。最常见的副作用是痤疮（持续2-3周），干燥唇（唇炎），干燥和脆弱的皮肤的瞬时恶化，和对晒伤的敏感性增加。罕见和罕见的副作用包括：肌肉疼痛和疼痛（肌痛）和头痛。由于分子与视黄酸（一种控制正常胚胎发育的天然维生素A衍生物）密切相似，异维甲酸已知由于在子宫内暴露中而引起先天缺陷。

在美国，需要一个特殊的程序来获得药物。在大多数其他国家，需要一个同意书来解释这些风险。服用异维A酸的妇女不得在异维A酸治疗后1个月内怀孕。在此期间，强制性禁欲或有效避孕。由于不可接受的失败率约3％，自身的屏障方法（例如避孕套）不被认为是足够的。在异维A酸治疗期间怀孕的妇女通常被建议终止。异维A酸对男性生殖无影响。

用法：

异维甲酸主要用于对其他治疗无反应的严重囊性痤疮和痤疮。痤疮治疗通常以局部用类维生素A（例如维甲酸，阿达帕林）与局部用抗生素（例如克林霉素，红霉素）或防腐剂（例如，含过氧化苯甲酰的制剂），然后口服抗生素（例如多西环素或米诺环素）。在妇女中，含有醋酸环丙孕酮的避孕药可能有用，如果没有禁忌症。

在激素性痤疮的情况下，例如在具有周期性痤疮的20多岁和30多岁的女性中，通常一段异维A酸可以永久地改善痤疮，消除对终生激素操作的需要。

注意：异维A酸不能被怀孕或怀孕的患者服用。存在高度风险的异维A酸将导致丧失怀孕，或将导致婴儿出生得太早，出生后不久死亡，或出生时出生缺陷（出生时存在的身体问题）。

剂量：

所接受的异维A酸的剂量取决于它们的体重和病症的严重程度。高剂量治疗以0.5mg / kg /天至2mg / kg /天（通常为0.5至1mg / kg /天，作为与食物的单剂量给予）施用。通常一个课程将持续8-10个月。可能需要第二个课程。效力似乎与所采取的异维A酸的累积剂量有关，其中每个疗程的总累积剂量为120-150mg / kg用作指导。

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Effective Pharma Grade Material Isotretinoin for Acne Treatment

Product Details:

Isotretinoin Synonym: 13-cis-ra; 13-cis-retinoicaci; 13-ra; Isoretinoin; Isotrex; Neovitaminaacid; RO-4-3780
Isotretinoin CAS: 4759-48-2
Isotretinoin MF: C20H28O2
Isotretinoin MW: 300.44
Isotretinoin EINECS: 225-296-0
Isotretinoin Assay: 99%
Isotretinoin Appearance: Orange Crystal Powder
Isotretinoin Specification: USP
Isotretinoin Usage: As the retinoid, there are strong and fast proliferation inhibition and differentiation of skin gland cell function, effective on severe nodular cystic acne. The gastrointestinal absorption is better, while the local medication invalid. Other drugs used to treat invalid serious acne, cystic acne, acne conglobata, rosacea, ichthyosis, keratosis follicularis and pityriasis rubra pilaris and other skin diseases also have a certain effect.
Isotretinoin For severe acne. Anti skin dyskeratosis medicine. For the treatment of severe acne and other disorders.

Description:

Isotretinoin (INN) (etymology and pronunciation), also known as 13-cis retinoic acid, is an oral pharmaceutical drug primarily used to treat cystic acne. Rarely, it is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis. It is a retinoid, meaning it is related to vitamin A, and is found in small quantities naturally in the body. Its isomer, tretinoin, is also an acne drug.

Isotretinoin is primarily used as a treatment for severe acne. The most common adverse effects are a transient worsening of acne (lasting 2-3 weeks), dry lips (cheilitis), dry and fragile skin, and an increased susceptibility to sunburn. Uncommon and rare side effects include: muscle aches and pains (myalgias), and headaches. Isotretinoin is known to cause birth defects due to in utero exposure because of the molecule's close resemblance to retinoic acid, a natural vitamin A derivative which controls normal embryonic development.

In the United States a special procedure is required to obtain the pharmaceutical. In most other countries a consent form is required which explains these risks. Women taking isotretinoin must not get pregnant during, and for 1 month after isotretinoin therapy. Sexual abstinence, or effective contraception is mandatory during this period. Barrier methods by themselves (such as condoms) are not considered adequate due to the unacceptable failure rates of approximately 3%. Women who fall pregnant whilst on isotretinoin therapy are generally counselled to have a termination. Isotretinoin has no effect on male reproduction.

Usage:

Isotretinoin is used primarily for severe cystic acne and acne that has not responded to other treatments.[3][4] Acne treatment usually begins with topical retinoids (e.g., tretinoin, adapalene), in combination with topical antibiotics (e.g., clindamycin, erythromycin) or antiseptics (e.g., benzoyl peroxide-containing preparations), followed by oral antibiotics (e.g., doxycycline or minocycline). In women a cyproterone acetate-containing contraceptive pill can be useful if there are no contraindications.

In cases of hormonal acne, such as in women in their 20s and 30s with cyclical acne, often a course of isotretinoin can permanently improve acne obviating the need for lifelong hormonal manipulation.

Notes: Isotretinoin must not be taken by patients who are pregnant or who may become pregnant. There is a high risk that isotretinoin will cause loss of the pregnancy, or will cause the baby to be born too early, to die shortly after birth, or to be born with birth defects (physical problems that are present at birth).

Dosage:

The dose of isotretinoin patients receive is dependent on their weight and the severity of the condition. High-dose treatments are administered between 0.5 mg/kg/day to 2 mg/kg/day (usually at 0.5 to 1 mg/kg/day, given as a single dose with food). Usually a course will last 8-10 months. A second course may be required. Efficacy appears to be related to the cumulative dose of isotretinoin taken, with a total cumulative dose over each course of 120-150 mg/kg used as a guideline.

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