CAS 850-52-2孕激素雌激素类固醇激素Altrenogest

1.产品详细：
Altrenogest
同义词：11-三烯-3-酮，17-α-烯丙基-17-羟基 - 雌甾-9,17-烯丙基环戊唑啉; 17-α-烯丙基 - 雌三烯-4,9,11,17- 17-羟基-17-（2-丙烯基） - （17-β） - 雌甾-11-三烯-3-酮; drc6246; r2267; ru2267; ALLYLTRENBOLONE
CAS登记号：850-52-2
测定：99％
分子式：C21H26O2
分子量：310.43
外观：淡黄色结晶或粉末
最小订货量：10g
它是一种结构上与兽医类固醇trenbolone相关的孕激素。
Altrenogest是合成的三烯C21类固醇孕激素，属于19-去甲睾酮系列。它是一种口服活性（促）孕激素。像所有类固醇，altrenogest通过其脂溶性通过穿透靶细胞，其中它结合特定受体行动。在兽医学中，altrenogest用于小母猪和母马用于动物技术目的（发情同步）。
目标：孕酮受体

Altrenogest是与兽医类固醇trenbolone结构相关的孕激素。用altrenogest治疗胚胎接受者母马似乎有益于延长成功胚胎移植所需的供体 - 受体同步的程度。 Altrenogest治疗似乎对于经历黄体功能障碍'1'的受试者的妊娠维持是导电的。油和凝胶altrenogest制剂同样有效调节发情行为和时间到发情和排卵。
在炎症晚期开始的Altrenogest治疗似乎导致在治疗期间排卵的高发生率，并且当治疗期间发生解剖和排卵时;由于CL的退化的失败，随后的黄体期经常延长。

使用：
Altrenogest指示（标记）以抑制母马中的发情，以允许在药物撤出后更可预测地发生发情。它在临床上用于帮助母马在从麻醉到正常繁殖季节的过渡期间建立正常的周期，通常与人工光周期结合。在过渡期后期更有效地协助怀孕。一组作者（Squires等人，1983）建议选择具有相当大的毛囊活性的母马（具有一个或多个20mm或更大的卵泡的母马）用于在过渡阶段期间进行治疗。已经发情10天或更长时间且具有活动性卵巢的母马也被认为是孕激素治疗的极好候选者。

Altrenogest在正常循环母马中有效，以最小化发情检测的必要性，用于发情同步并允许预定育种。 Estrus将在治疗完成后2-5天继续，并且大多数母马在取出后8-15天排卵。 Altrenogest还有效地抑制显示母马或母马的发情表达。虽然药物在怀孕期间被标记为禁忌，已经证明在卵巢切除的母马中维持怀孕，并且可能对由于亚治疗性孕激素水平而中止的母马有益。

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CAS 850-52-2 Progesterone Estrogen Steroids Hormones Altrenogest

1. Product details:
Altrenogest
Synonym: 11-trien-3-one,17-alpha-allyl-17-hydroxy-estra-9;17-allyltrenbolone;17-alpha-allyl-estratriene-4,9,11,17-beta-ol-3-one;17-hydroxy-17-(2-propenyl)-(17-beta)-estra-11-trien-3-one;drc6246;r2267;ru2267;ALLYLTRENBOLONE
CAS Registry Number: 850-52-2
Assay: 99%
Molecular Formula: C21H26O2
Molecular Weight: 310.43
Appearance: Light yellow crystal or powder
Min order:10g
Itis a progestogen structurally related to veterinary steroid trenbolone.
Altrenogest is a synthetic trienic C21 steroidal progestomimetic, belonging to the 19-nor-testosterone series. It is an orally active (pro)gestagen. Like all steroids, altrenogest acts by its liposolubility by penetrating the target cells where it binds to specific receptors. In veterinary medicine, altrenogest is used in gilts and mares for zootechnical purposes (oestrus synchronization).
Target: Progesterone Receptor

Altrenogest is a progestogen structurally related to veterinary steroid trenbolone. Treatment of embryo-recipient mares with altrenogest appears to be beneficial in extending the degree of donor-recipient synchrony required for successful embryo transfer. Altrenogest treatment also seems to be conductive to pregnancy maintenance in recipients experiencing luteal dysfunction [1]. The oil and gel altrenogest preparations are equally effective in modulating estrous behavior and time to estrus and ovulation.
Altrenogest treatment started late in diestrus appears to result in a high incidence of ovulation during treatment and when luteolysis and ovulation occur during treatment; the subsequent luteal phase is frequently prolonged due to failure of regression of the CL.

Use:
Altrenogest is indicated (labeled) to suppress estrus in mares to allow a more predictable occurrence of estrus following withdrawal of the drug. It is used clinically to assist mares to establish normal cycles during the transitional period from anestrus to the normal breeding season often in conjunction with an artificial photoperiod. It is more effective in assisting in pregnancy attainment later in the transition period. One group of authors (Squires et al. 1983) suggest selecting mares with considerable follicular activity (mares with one or more follicles 20 mm or greater in size) for treatment during the transitional phase. Mares that have been in estrus for 10 days or more and have active ovaries are also considered to be excellent candidates for progestin treatment.

Altrenogest is effective in normally cycling mares for minimizing the necessity for estrus detection, for the synchronization of estrus and permitting scheduled breeding. Estrus will ensue 2-5 days after treatment is completed and most mares ovulate between 8-15 days after withdrawal. Altrenogest is also effective in suppressing estrus expression in show mares or mares to be raced. Although the drug is labeled as contraindicated during pregnancy, it has been demonstrated to maintain pregnancy in oophorectomized mares and may be of benefit in mares who abort due to sub-therapeutic progestin levels.

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