基本信息
型号：1mg /瓶
定制：非定制
适合：成人
纯度：> 99％; 99％
外观：冻干粉
名称：Ace-031 / Acvr2b / Follistatin 344 / Follistatin 315
政策：重组政策
商标：泉澳
原产地：中国
粉：是的
认证：gmp，hse，iso 9001，usp，bp
状态：坚实
测定：99％
品牌：泉澳
快递：ems，hkems tnt，ups，dhl，fedex，hk邮寄
成绩标准：医学级
规格：1mg /瓶
HS编码：9601900090
产品描述
健美成长肽Follistatin 344 / Follistatin 315 / ACE 031 1mg /小瓶
健美成长肽Follistatin 344 / Follistatin 315 / ACE 031 1mg /小瓶
健美成长肽Follistatin 344 / Follistatin 315 / ACE 031 1mg /小瓶
Follistatin（FST）是一种分泌型糖蛋白，首先在卵泡液中被鉴定为促卵泡激素抑制物质（1,2）。人类Follistatin cDNA用29aa信号序列，Nterminal非典型TGF结合结构域，3个含有EGF样和kazallike基序的Follistatin结构域以及高度酸性的C末端尾端编码344个氨基酸（aa）蛋白。 Follistatin是分泌的蛋白质，其结合TGF-β家族的配体并通过抑制它们进入信号受体来调节其活性。它最初被发现作为激活素拮抗剂，其活性抑制垂体激素FSH（促卵泡激素）的表达和分泌。除了是天然拮抗剂外，卵泡抑素可以抑制其他TGF-β配体的活性，包括BMP-2，-4，-6，-7，肌生成抑制素，GDF-11和TGF-β1。卵泡抑素在垂体，卵巢，子宫内膜的蜕膜细胞和其他组织中表达。重组人Follistatin是含有344个氨基酸的37.8kDa蛋白质。
Follistatin和肌肉生长：
Follistatin通过结合和抑制负责调节和限制肌肉生长的转化生长因子（TGF-β）肽如肌肉生长抑制素起作用。还有一点值得指出的是，肌生成抑制素可能在骨骼肌纤维化中具有调节作用;肌生成抑制素过多会损害组织功能，并在重要的器官，组织和骨髓中引起慢性疾病。
除抑制肌生成抑制素的退行性外，卵泡抑素也抑制垂体腺合成和促卵泡激素（FSH）的分泌。 '1'男性高FSH水平可能表明睾丸功能不正常;这种情况限制肌肉生长，恢复和正常的荷尔蒙功能。然而，过低的FSH水平也可能对健康和生殖能力产生负面影响。
ACE-031仅用于研究目的。 ACE-031不应用于人类消费，诊断，治疗程序，农业和兽医目的。
ACE-031是一种可溶性融合蛋白，已经显示出在研究中增加肌肉质量和强度。正在研究ACE-031作为代谢疾病，儿童肾脏肿瘤，心血管异常，与年龄相关的肌肉损失以及癌症治疗相关的肌肉损失和神经肌肉疾病的治疗。 ACE-031是一种基于激活素受体IIB型（ActRIIB）的生物治疗剂。该分子通过ActRIIB受体结合抑制信号传导，并增加肌肉质量和强度。 ACE-031是通过融合标准抗体和部分ActRIIB受体人工合成的重组融合蛋白。重组融合蛋白消除肌生成抑制素和其他限制肌肉力量或生长的生物分子。
Follistatin是令人着迷的蛋白质，通过抑制肌生成抑制素可以增加肌肉质量超过天然的潜力。科学家在检查卵巢中的猪（re：pig）滤泡液时首先确定了卵泡抑素。
几乎所有具有先进或发达特征的哺乳动物，如人，啮齿动物和奶牛，骨骼肌中天然存在氟积累。 Follistatin是高的
非必需氨基酸胱氨酸，但不同于健身世界中讨论的大多数蛋白质，卵泡抑素具有附着的碳水化合物。
Follistatin，特别是Follistatin 344（FS344），在健美社区中迅速普及，作为快速增加瘦肉组织量的潜在补充。另一种蛋白质，卵泡抑素相关基因（FLRG）与FS344的肌肉建构性质相似。增加的瘦肉组织量可以使健美运动员在竞争环境中具有优势，成为第一和第二位差异因素。
卵泡抑素（FS）最初被鉴定为在卵泡滤泡液中发现的促卵泡激素抑制物质。 FS是可以作为激活素拮抗剂的高亲和力激活素结合蛋白。存在两个可变剪接的卵泡抑素mRNA，编码具有288个氨基酸（aa）残基（FS-288）和315个氨基酸残基（FS-315）的成熟FS。从猪卵巢中纯化的天然FS主要是由300aa残基组成的FS-315的羧基末端截短形式。
肽产品列表

Basic Info
Model NO.: 1mg/vial
Customized: Non-Customized
Suitable for: Adult
Purity: ﹥99%;99%
Appearant: Lyophilized Powder
Name: Ace-031/Acvr2b /Follistatin 344/Follistatin 315
Policy: Reshipping Policy
Trademark: QuanAO
Origin: China
Powder: Yes
Certification: GMP, HSE, ISO 9001, USP, BP
State: Solid
Assay: 99% Min.
Brand: Quanao
Express: EMS, Hkems TNT, UPS, DHL, FedEx, HK Post Mail
Grade Standard: Medicine Grade
Specification: 1mg/vial
HS Code: 9601900090
Product Description
Bodybuilding Growth peptides Follistatin 344/Follistatin 315/ACE 031 1mg/vial
Bodybuilding Growth peptides Follistatin 344/Follistatin 315/ACE 031 1mg/vial
Bodybuilding Growth peptides Follistatin 344/Follistatin 315/ACE 031 1mg/vial
Follistatin (FST) is a secreted glycoprotein that was first identified as a follicle stimulating hormone inhibiting substance in ovarian follicular fluid (1, 2). Human Follistatin cDNA encodes a 344 amino acid (aa) protein with a 29 aa signal sequence, an Nterminal atypical TGF binding domain, three Follistatin domains that contain EGFlike and kazallike motifs, and a highly acidic Cterminal tail. Follistatin is a secreted protein that binds to ligands of the TGF-Beta family and regulates their activity by inhibiting their access to signaling receptors. It was originally discovered as activin antagonists whose activity suppresses expression and secretion of the pituitary hormone FSH (follicle stimulating hormone). In addition to being a natural antagonist, follistatin can inhibit the activity of other TGF-Beta ligands including BMP-2, -4, -6, -7, Myostatin, GDF-11, and TGF-Beta1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Recombinant human Follistatin is a 37.8 kDa protein containing 344 amino acids .
Follistatin and Muscle Growth:
Follistatin works by binding to and inhibiting transforming growth factor- (TGF-) peptides such as myostatin which is responsible for regulating and limiting muscle growth. It's also worth pointing out that myostatin may have a regulatory role in skeletal muscle fibrosis; too much myostatin can impair tissue function and cause chronic disease in vital organs, tissues, and bone marrow.
In additional to suppressing the degenerative properties of myostatin, follistatin also suppresses the pituitary gland synthesis and secretion of follicle-stimulating hormone (FSH). [1] High FSH levels in men may indicate that testicles are not functioning correctly; this condition limits muscle growth, recovery, and normal hormonal function.However, FSH levels that are too low can also negatively impact health and reproductive capabilities.
ACE-031 is intended for research purpose only. ACE-031 should not be used for human consumption, diagnostic, therapeutic procedures, agricultural and veterinary purposes.
ACE-031 is a soluble fusion protein that has been shown to increase muscle mass and strength in research studies. ACE-031 is being studied as a treatment for metabolic diseases, renal neoplasms of childhood, cardiovascular anomalies, age-related muscle loss, and cancer treatment related muscle loss and neuromuscular diseases. ACE-031 is a biologic therapeutic, based on activin receptor type IIB (ActRIIB). The molecule inhibits signaling via the ActRIIB receptor binding and increase muscle mass and strength. ACE-031 is a recombinant fusion protein that is artificially synthesized by fusion of standard antibody and a portion of ActRIIB receptor. The recombinant fusion protein eliminates myostatin and other biomolecules that limit muscle strength or growth.
Follistatin is fascinating protein that can increase muscle mass beyond natural potential by suppressing myostatin. Scientists first identified follistatin while examining porcine (re: pig) follicular fluid in the ovaries.
Follistatin is naturally found in the skeletal muscle of almost all mammals with advanced or developed characteristics, such as humans, rodents, and cows. Follistatin is high in the
non-essential amino acid cystine but unlike most proteins discussed in the fitness world, follistatin has carbohydrates attached to it.
Follistatin, specifically Follistatin 344 (FS344), quickly gained popularity in the bodybuilding community as a potential supplement to rapidly increase lean tissue mass. Another protein, follistatin-related gene (FLRG) acts on similar pathways as FS344 regarding its muscle building properties. Increased lean tissue mass could give a bodybuilder an advantage in a competitive setting and be the differentiating factor between first and second place.
Follistatin (FS) was initially identified as a follicle-stimulating hormone inhibiting substance found in ovarian follicular fluid. FS is a high-affinity activin-binding protein that can act as an activin antagonist. Two alternatively spliced follistatin mRNAs exist, encoding mature FS with 288 amino acid (aa) residues (FS-288) and 315 aa residues (FS-315). Natural FS purified from porcine ovaries is primarily a carboxy-terminal truncated form of FS-315 composed of 300 aa residues.
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