肌肉生长同化肽激素 Pentadecapeptide cas 137525-51-0 bpc 157
基本信息。
型号: cas 137525-51-0
粉: 是
自定义: 自定义
认证: gmp, iso 9001, usp, bp
适用于: 成人
状态: 实心
纯度: ﹥99%; 99%
cas: 137525-51-0
分子式: c62h98n16o22
分子量: 1419.53552
外观: 白色冻干粉
别名: Booly 保护化合物15
商标: sm
运输包装: 伪装包装为送货保证!
规格: 2 毫克/瓶
产地: 中国
hs 代码: 2937390000
产品介绍
肌肉生长同化肽激素 Pentadecapeptide bpc 157
快速详细信息:
Pentadecapeptide bpc 157, 由15种氨基酸组成, 是一个部分序列的身体保护化合物 (bpc), 发现和分离的人胃液。实验证明它能加速许多不同创伤的愈合, 包括断大鼠跟腱。本研究旨在探讨 bpc 157 的潜在机制, 以加强损伤肌腱的愈合。研究了用或无原料药157培养的肌腱成纤维细胞的生长情况。结果表明, 原料药157显著加快了肌腱外植体的生长。用 mtt 法测定大鼠跟腱的培养的肌腱成纤维细胞的增殖不直接受 bpc 157 的影响。然而, 在 h (2) o (2) 应力下, bpc 157 处理后的细胞存活明显增加。bpc 157 显着增加了肌腱成纤维细胞的体外迁移的剂量依赖性的方式揭示了 transwell 过滤迁移试验。bpc 157 还剂量依赖加速肌腱成纤维细胞在培养皿中的传播。fitc-笔染色检测到157处理的成纤维细胞的 f-肌动蛋白形成。用免疫印迹分析法测定了 fak 和蛋白的蛋白表达和活化, fak 和蛋白的磷酸化水平均为原料药157的剂量依赖性增加, 而蛋白质的总含量未改变。最后, bpc 157 促进肌腱成纤维细胞的前体生长, 从腱外植块, 在压力下的细胞存活, 和肌腱成纤维细胞的体内迁移, 这很可能介导的 fak-蛋白途径的活化。

bpc 157 在急性和慢性炎症模型中具有强烈的抗炎活性。事实上, 临床试验的初步结果表明, bpc 157 可能成为治疗炎症性肠病的重要治疗工具。bpc 157 被证明能加速伤口愈合并具有明显的血管生成作用。此外, 它大大促进了大鼠骨骨折的愈合。该肽还具有成骨作用, 显著改善了节段性骨缺损的愈合。bpc 157 加速了断大鼠跟腱和断大鼠股四头肌的愈合。

Muscle Growth Anabolic Peptide Hormone Pentadecapeptide CAS 137525-51-0 Bpc 157
Basic Info.
Model NO.: CAS 137525-51-0
Powder: Yes
Customized: Customized
Certification: GMP, ISO 9001, USP, BP
Suitable for: Adult
State: Solid
Purity: ﹥99%;99%
CAS: 137525-51-0
Molecular Formula: C62h98n16o22
Molecular Weight: 1419.53552
Appearance: White Lyophilized Powder
Alias:Booly Protection Compound 15
Trademark: SM
Transport Package: Disguised Packing for Delivery Guarantee!
Specification: 2mg/vial
Origin: China
HS Code: 2937390000
Product Description
Muscle Growth Anabolic Peptide Hormone Pentadecapeptide BPC 157
Quick Detail:
Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from human gastric juice. Experimentally it has been demonstrated to accelerate the healing of many different wounds, including transected rat Achilles tendon. This study was designed to investigate the potential mechanism of BPC 157 to enhance healing of injured tendon. The outgrowth of tendon fibroblasts from tendon explants cultured with or without BPC 157 was examined. Results showed that BPC 157 significantly accelerated the outgrowth of tendon explants. Cell proliferation of cultured tendon fibroblasts derived from rat Achilles tendon was not directly affected by BPC 157 as evaluated by MTT assay. However, the survival of BPC 157-treated cells was significantly increased under the H(2)O(2) stress. BPC 157 markedly increased the in vitro migration of tendon fibroblasts in a dose-dependent manner as revealed by transwell filter migration assay. BPC 157 also dose dependently accelerated the spreading of tendon fibroblasts on culture dishes. The F-actin formation as detected by FITC-phalloidin staining was induced in BPC 157-treated fibroblasts. The protein expression and activation of FAK and paxillin were determined by Western blot analysis, and the phosphorylation levels of both FAK and paxillin were dose dependently increased by BPC 157 while the total amounts of protein was unaltered. In conclusion, BPC 157 promotes the ex vivo outgrowth of tendon fibroblasts from tendon explants, cell survival under stress, and the in vitro migration of tendon fibroblasts, which is likely mediated by the activation of the FAK-paxillin pathway.

BPC 157 has a strong anti-inflammatory activity in both acute and chronic inflammation models. In fact, preliminary results in clinical trials suggest that BPC 157 may become an important therapeutic tool for the treatment of inflammatory bowel disease. BPC 157 was shown to accelerate wound healing and to have a marked angiogenic effect. In addition, it significantly facilitates the healing of bone fracture in rats. This peptide also exhibits an osteogenic effect significantly improving the healing of segmental bone defect. BPC 157 accelerates the healing of transected rat Achilles tendon and transected rat quadriceps muscle.