枸橼酸他莫昔芬（诺瓦得士，54965-24-1）
化学名：（Z）-2- [4-（1,2二苯基-1-丁烯基）苯氧基] -N，N-二甲基乙胺柠檬酸盐;
别名：Farmifeno; Oncomox; Tafoxen; Kessar; Tamoxasta; Soltamox; Noxitem; Oncotam
分子式：C26H29NO。 C6H8O7
分子量：563.64
CAS：54965-24-1
EINECS：259-415-2
含量：99.0〜101.0％
外观：白色结晶性粉末
标准：企业标准
熔点：140-144℃，
沸点：665.9℃，760毫米汞柱
闪点：356.5℃，
溶解性：微溶于水
用途：非甾体抗雌激素。 用于晚期，转移性乳腺癌treatemnt。
存储：在黑暗和寒冷的地方

他莫昔芬是通过其活性代谢物，hydroxytamexifen乳腺组织中的雌激素受体的拮抗剂。 在其它组织，如子宫内膜，他莫昔芬表现为激动剂。 因此三苯氧胺也许被表征为一个混合的激动剂，他莫昔芬已被标准内分泌治疗激素受体阳性乳腺癌早期在绝经前妇女，虽然芳香酶抑制剂已提议。 他莫昔芬被发现由ICI药品。

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Tamoxifen Citrate (Nolvadex, 54965-24-1)
Chemical Name: (Z) -2-[4-(1, 2-Diphenyl-1-butenyl)phenoxyl]-N, N-dimethyl-ethanamine-citrate;
Synonyms: Farmifeno; Oncomox; Tafoxen; Kessar; Tamoxasta; Soltamox; Noxitem; Oncotam
Molecular Formula: C26H29NO. C6H8O7
Molecular weight: 563.64
CAS: 54965-24-1
EINECS: 259-415-2
Assay: 99.0~101.0%
Appearance: White crystalline powder
Standard: Enterprise Standard
Melting Point: 140-144 ° C
Boiling Point: 665.9 ° C at 760 mmHg
Flash Point: 356.5 ° C
Solubility: Slightly soluble in water
Usage: A nonsteroidal antiestrogen. Used for treatemnt of advanced, metastatic breast cancer.
Storage: In dark and cold place

tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, hydroxytamexifen. in other tissue such as the endometrium, tamoxifen behaves as an agonist. Hence tamoxifen maybe be characterized as a mixed agonist, tamoxifen has been the standard endocrine therapy for hormone receptor-postive early breast cancer in pre-menopausal women, although aromatase inhibitors has been proposed. tamoxifen was discovered by ICI pharmaceuticals.

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