Anesthesia Prilocaine 721-50-6 Effective Pain Reliver Topical
prilocaine Profile
Product Name: Prilocaine
Synonyms: 2-(propylamino)-o-propionotoluidid;
CAS: 721-50-6
MF: C13H20N2O
MW: 220.31
EINECS: 211-957-0
Product Categories: Active Pharmaceutical Ingredients
Packing:Foil bag or as requirments
Pharmacological effects of prilocaine
Amide family of local anesthetics, the role of similar to lidocaine, but a longer time. No vasodilator effect, less toxic, accumulation is also small.
Pharmacokinetics of prilocaine
A considerable part of the lung metabolism or separation (sequester), in the body by the rapid degradation of the liver metabolism, toxicity than lidocaine.
Indications of prilocaine
For epidural anesthesia, block anesthesia and infiltration anesthesia.
Contraindications of prilocaine
Anemia, congenital or spontaneous degeneration of hemoglobin patients disabled, pregnant women with caution.
Precautions
1. Currently no longer commonly used clinically, mainly for local infiltration anesthesia and local intravenous anesthesia.
2. A maximum of 600mg.
Adverse effects of prilocaine
When the dose of more than 600mg, the metabolism of o-toluidine, hemoglobin reduction for the hemoglobin, and the blood methemoglobin more than 1.5g / dl, the clinical may be cyanosis, hemoglobinuria and other complications. In the event, to be 1mg / kg of methylene blue can be effective treatment of methemoglobinemia.
Dosage of prilocaine
Infiltration anesthesia with 1% solution; a variety of nerve block or epidural anesthesia with 2% or 3% solution.
Interaction of prilocaine with other drugs
In patients receiving other medications (such as sulfonamides) that can cause methemoglobinemia, prilocaine can aggravate methemoglobin formation. See lidocaine hydrochloride.

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