High Purity Pharmaceutical Raw Material Pirfenidone CAS 53179-13-8
Product Description:

Pirfenidone
CAS: 53179-13-8
MF: C12H11NO
FW:185.22
Other Name: 5-Methyl-N-phenyl-2-1H-pyridone
Appearance: White crystal powder
Melting point: 102--109
Solubility: DMSO: 10 mg/mL, soluble
Loss on drying <1.0%1.0%
Known single impurity <1.0%1.0%
Unknown single impurity <0.5%0.5%
Total impurity <2.0%2.0%
Assay(as dried) 99%min
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Application:
In vitro, pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation. Pirfenidone can inhibit the TGF - beta - 1 inducing fibroblast collagen formation. Inhibition of PDGF, FGF and TGF - beta - 1 inducing fibroblast proliferation. In hamster model, pirfenidone, taken by mouth, that can the prevention and treatment of pulmonary fibrosis induced by bleomycin. Pirfenidone can prevent the sclerosing peritonitis in rats induced by chemical, can also be keloid grafting for the treatment of nude mice. Pirfenidone 0.01 1 mg/ml can suppress the matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also. Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and lung preserved ammonia acyl hydroxylase activity.

Uses
Pirfenidone is used to treat mild to moderate forms of a certain lung disease called idiopathic pulmonary fibrosis (IPF). This disease causes the lungs to get scarred and become stiff, making it hard to breathe. Pirfenidone may help slow down the worsening of your IPF.
How to use pirfenidone
Read the Patient Information Leaflet if available from your pharmacist before you start taking pirfenidone and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth with food as directed by your doctor, usually 3 times a day. Taking pirfenidone with food helps to decrease dizziness and nausea. Also, to reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose over 2 weeks. Follow your doctor's instructions carefully.
Swallow the capsules whole with water.
The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all.