Fragment 176-191 AOD-9604 Pharmaceutical Intermediate

Description
AOD-9604 is a peptide fragment of the C-terminus of (Tyr177-191) to which a tyrosine is added at the N-terminus. Studies have suggested that AOD-9604 is more effective than its predecessor AOD-9401 in its ability to stimulate lipolytic and anti-lipogenic activity. AOD-9604 stimulates lipolysis (the breakdown of fat) and inhibits lipogenesis (prevents the transformation of fatty food materials into body fat) both in laboratory testing and in animals. In laboratory tests on fat cells from rodents, the fragment released fat specifically from obese fat cells and reduced new fat accumulation in all fat cells.
Specification
Name: AOD-9604
Synonyms: Fragment 177-191
CAS #: 221231-10-3
Molecular Formula: C50H68N14O10
Molecular Mass: 1815.08 Da (g/mol)
Amino Acid Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
Purity
AOD-9604 has a peptide purity level that exceeds 99.0% as determined by HPLC and MS. This peptide was synthesized with no additives and is supplied as a white lyophilized (freeze-dried) powder.
Usage
In laboratory tests on fat cells from rodents, pigs, dogs, and humans, the fragment released fat specifically from obese fat cells but not from lean ones, reduced new fat accumulation in all fat cells, enhanced the burning of fat. In rodents (rats and mice), fragment reduced body fat in obese animals but, enhanced fat burning without changing food consumption or inducing growth (as it does not increase levels) or any other unwanted effect. Recent research has shown AOD9604 to be an extremely potent and effective fat burner. Metabolic is developing AOD-9604 for the potential treatment of obesity. Research studies have shown that AOD9604 actually acts on the reduction of excessive adipose tissues such as those in the abdominal area, increase in muscle mass, and enhances the lipid content of the body.
These segments of the synthetic peptide AOD9604 have been researched for their in vivo effects in laboratory mice musculus. Results have shown that AOD9604 have resulted to a short-period increase in blood glucose and a more sustained increase in plasma insulin, together with other fragments such as 172-191, 177-191 and 178-191. In addition, the researchers have suggested that functionality of the peptide depends not only in the informational sequence but should also have the correct physical configuration (Ng and Borstein 1978). Also, AOD9604, being a region of high accessibility to proteases and also rich in proline, have been demonstrated to affect the conformational change in the cytoplasmic domain of the band 3 of erythrocyte membrane protein by serving as the hinge for the pivoting of the two subdomains. This then suggest that such residue is significant in conformational changes be serving as sites for peripheral protein binding in some body cells (Low et al. 1984).