Benzocaine HCL/ hydrochloride Pharmaceutical Intermediates for anaesthetic drug
Quick Detail;
Benzocaine HCL
CAS: 23239-88-5
Assay: 99.8%min
Appearance: White crystals
Water: 1.0%max
MP: 208 Celsius degree
Description;
Benzocaine is an anaesthetic drug, mostly used for application direct to the skin. Benzocaine HCl is a salt modification of benzocaine, formed when benzocaine is complexed with hydrochloric acid. Often, drug salts have enhanced properties compared with the parent compound.
COA
| Items | QUALITY STANDARDS | RESULTS |
| Description | White or almost white crystalline powder | White crystalline powder |
| Solubility | Matching with the working standard | Complies |
Identification | A.By IR, To match with working standard | Complies |
| B: To 10ml of solution S add 1ml of ammonium thiocyanate solution R.A white,crystalline precipitate is formed which,after recrystallisation from water R and drying at 80ºC for 2h,melts at about 131ºC 131ºCrdm;C 131ºC | Complies |
| C. To about 5mg add 0.5ml of fuming nitric acid R .Evaporate to dryness on a water-bath,allow to cool and dissolve the residue in 5ml of acetone R.Add 1ml of 0.1M alcoholic potassium hydroxide.A violet colour develops | Complies |
| | D. Solution S gives reaction of chlorides. | Complies |
| PH | 4.5~6.5 | 5.78 |
| Residual Solvents | Conform to standard | Complies |
| Claruty | Solution should be clear | Complies |
| Related Substances | Conform to standard | Complies |
| Heavy metals | ≤10ppm0ppm0ppm | <10ppm0ppm |
| Loss on drying | ≤1.0%1.0%1.0% | 0.87% |
| Resiue on ignition | ≤0.1%0.1%0.1% | 0.05% |
| Melting range | 148ºCordm;Cordm;C | 147.5ºC~150.8ºC50.8ºCrdm;C50.8ºC |
| Assay | 99%~101.0% | 100.40% |
| Conclusion | The Sample Complies With Specification of EP8 |
Decriptions;
Benzocaine - A surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
Horf (Benzocaine) is a local anesthetic commonly used as a topical pain reliever. It is the active ingredient in many over-the-counter analgesic ointments. It is also indicated for general use as a lubricant and topical anesthetic on intratracheal catheters and pharyngeal and nasal airways to obtund the pharyngeal and tracheal reflexes; on nasogastric and endoscopic tubes; urinary catheters; laryngoscopes; proctoscopes; sigmoidoscopes and vaginal specula.
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| Test Acetate | 1045-69-8 | Methyldrostanolone | 3381-88-2 |
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| Test Cypionate | 58-20-8 | Methnolone Acetate | 434-05-9 |
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| Tren | 10161-33-8 | Melanotan-2 | 121062-08-6 |
| Tren Acetate | 10161-34-9 | GHRP-2 | 158861-67-7 |
| Ghrp-6 | 87616-84-0 | Ipamorelin | 170851-70-4 |
| Hexarelin | 140703-51-1 | Sermorelin | 86168-78-7 |
| Oxytocin | 158861-67-7 | PT141 | 87616-84-0 |