Phamaceutical raw materials Levobupivacaine Hydrochloride for local anaesthetic
Quick detail;
Chemical Name:Levobupivacaine hydrochloride
Synonyms;BUPIVACAINE HCL;(S)-Bupivacaine;LEVAMISOLHCLSALT;L-(-)-Bupivacaine;TIMTEC-BB SBB001337;LEVOBUPIVACAINE HCL;(S)-(-)-Bupivacaine;(S)-(-)-BUPIVACAINE HCL
CBNumber:CB3408801
CAS;27262-48-2
Molecular Formula;C18H29ClN2O
assay;≥98% (HPLC)PLC)PLC)
optical activity;[α]/D -10 to -14°, c = 1.0 in H2O 1.0 in H2O 1.0 in H2O
Specifications:

Description;
Levobupivacaine Hydrochloride is the hydrochloride salt of levobupivacaine, an amide derivative with anesthetic property. Levobupivacaine reversibly binds voltage-gated sodium channels to modulate ionic flux and prevent the initiation and transmission of nerve impulses (stabilizing neuronal membrane), thereby resulting in analgesia and anesthesia. In comparison with racemic bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action.
The bupivacaine molecule is a racemic compound. Levobupivacaine is the S-enantiomer of bupivacaine and is thought to have less cardiotoxic potential than the R-enantiomer. The pharmacokinetic parameters of levobupivacaine are similar to those of bupivacaine.
Application;
Levobupivacaine has been studied in surgical anaesthesia and for pain management. It can be used for local infiltration, epidural, intrathecal and peripheral nerve blocks. For epidural analgesia it can be given with clonidine. Double-blind comparisons of levobupivacaine and bupivacaine show that their anaesthetic effects are similar.
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