99% white Raw Local Anesthesia Agents powder Tetracaine HCL CAS136-47-0

99% white Raw Local Anesthesia Agents powder Tetracaine HCL CAS136-47-0

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99% white Raw Local Anesthesia Agents powder Tetracaine HCL CAS136-47-0
Alias: Tetracaine; Tetracaine HCl
CAS: 136-47-0
EINECS: 205-248-5
M.F.: C15H25ClN2O2
M.W.: 300.82
Appearance:White crystalline powder
Descroptions and Applications:
Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.
Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
The COA of Tetracaine:

Product nameTetracaine HCl
AppearanceWhite crystalline powder
Assay98~101.0%100.4%
IdentificationA.By UV, To match with working standardComplies

B:Dissolve 100 mg in 10 mL of water, and add 1 mL of potassium thiocyanate
Solution (1 in 4):A crystalline precipitate is formed.Recrystallize the precipitate
From water, and dry at 80 for 2 hours:It melts between 130 and 132 .		Complies

C.A solution of 100 mg in 5 mL of water meets the requirements of the
Tests for Chloride		Complies
PH
Chromatographic purity
Clarity		4.5~6.55.9

Conform to standardComplies

Solution should be clearComplies
Related SubstancesNot more than the reference solution (0.05%)Complies
Heavy metals≤10ppm<10ppm
Loss on drying<0.5%0.21%
Resiue on ignition≤0.1%0.05%
Melting range145~150°C146~149°C


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