Quick Detail:

Exemestane

Alias: Aromasin ; Exemestan;Exemestane

Product Category: Pharmaceutical raw materials and intermediates

Assay: 98%min

CAS Registry Number:107868-30-4

Molecular formula: C20H24O2

Molecular Weight:296.40

Appearance: White or Almost White Crystalline Powder

Grade : Pharmaceutical Grade

Storage: Shading, confined preservation

Delivery time :within 24 hours upon receipt of payment

Delivery: EMS, DHL, TNT, FedEx, UPS

Usage: Developed to help fight breast cancer, Aromasin is one of the most powerful estrogen suppressing compounds

Other drugs in same class:Anastrozole,Letrozole,Tamoxifen citrate,Exemestane

Description:

Exemestane is an oral steroidal aromatase inhibitor that is used in ER-positive breast cancer in addition to surgery and/or radiation in post-menopausal women.

The main source of estrogen is the ovaries in premenopausal women, while in post-menopausal women most of the body's estrogen is produced via the conversion of androgens into estrogen by the aromatase enzyme in the peripheral tissues (i.e. adipose tissue like that of the breast) and a number of sites in the brain. Estrogen is produced locally via the actions of the aromatase enzyme in these peripheral tissues where it acts locally. Any circulating estrogen in post-menopausal women as well as men is the result of estrogen escaping local metabolism and entering the circulatory system.

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Applications:

Exemestane is an oral steroidal aromatase inhibitor that is used in ER-positive breast cancer in addition to surgery and/or radiation in post-menopausal women.

The main source of estrogen is the ovaries in premenopausal women, while in post-menopausal women most of the body's estrogen is produced via the conversion of androgens into estrogen by the aromatase enzyme in the peripheral tissues (i.e. adipose tissue like that of the breast) and a number of sites in the brain. Estrogen is produced locally via the actions of the aromatase enzyme in these peripheral tissues where it acts locally. Any circulating estrogen in post-menopausal women as well as men is the result of estrogen escaping local metabolism and entering the circulatory system.

Exemestane is an irreversible, steroidal aromatase inactivator, structurally related to the natural substrate androstenedione. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation, an effect also known as 'suicide inhibition.' By being structurally similar to enzyme targets, Exemestane permanently binds to the enzymes, preventing them from converting androgen into estrogen.

Exemestane is taken in tablet form once a day. Patients can experience side effects like nausea, anxiety, shortness of breath, abdominal pain, bone pain, and chest pain. Side effects vary widely between patients and patients should report the side effects they experience to their doctors, as some may be indicators of dangerous complications. Shortness of breath and chest pain in particular are causes for concern in patients taking exemestane.

Exemestan Aromasin Use in bodybuilding

Certain anabolic androgenic steroids (AAS) convert to estrogen in the body; all testosterone esters, nandrolones, dianabol, and bolden are examples. If not controlled, the user runs the risk of developing several types of estrogenic side effects such as gynecomastia (bitch tits), water retention, blood pressure and heart problems. There is a domino effect that can occur if estrogen gets out of control. Just imagine carrying around two gallons of water all day!
The user may notice feeling rundown and tired, blood pressure will soar, and motivation will decrease. These side effects will defeat the purpose of running steroids in the first place. In addition, high estrogen levels, when coming off a cycle, will interfere with recovery of the bodies natural testosterone levels.
On the other hand, if you run a harsh AI, which eliminates too much estrogen, it can also have negative effects on libido, mood, and dry out the joints. Since aromasin is a suicide aromatase inhibitor, you should work on controlling the dosage and tailoring it to your cycle. Don't just use random dosages without looking at your whole steroid cycle.

Exemestane Effect

Aromasin is a suicidal aromatase inhibitor (AI), meaning it permanently disables the aromatase enzyme once it binds to it. In plain English, Aromasin will prevent the currently bound enzymes from rebounding, which is what separates this drug from letrozole or arimidex. When you use other AI' s, they temporarily stop estrogen from aromatizing, but when you stop taking them those same enzymes can rebound causing what is known as 'estrogen rebound' . This explains why some anabolic steroid users experience gynecomastia (bitch tits) after cycle when using other AI' s. Studies on breast cancer patients have shown aromasin reduced estrogen levels up to 85%.

Athletes commonly buy Aromasin to aid in their performance enhancement in conjunction with anabolic steroids. As an aromatase inhibitor Aromasin reduces the amount of estrogen in the body and this is precisely the reason any athlete will buy Aromasin. Make no mistake, Estrogen is essential to our overall well-being but this hormone is also damaging to a physique when levels become too high.When our estrogen levels are too high we will have difficulty in maintaining a lean and hard physique and if were using anabolic steroids a host of negative side-effects can rear their heads.This is why many steroid users buy Aromasin and with proper use they eliminate the potential problems associated with estrogen build up.

Aromasin Dosage

This is dependent on the individual and, also, the amount of aromatizing compounds the person is running. Generally, a good starting dose is 12.5mg ED (every day) or 25mg EOD (every other day). The user must utilize blood work to see how their body is reacting at the starting dosage they choose and then adjust as needed. Experienced anabolic steroid users will usually find a dose they like and stick to it with no problems. As I said already, if you start noticing joint issues then the dose should be lowered; on the other hand, if you start noticing any estrogen related sides, such as puffy or sensitive breasts or water retention, it' s time to increase the dosage.

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