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CAS:171596-29-5
MF:C22H19N3O4
MW:389.4
EINECS:200-835-2
Synonyms:TADALAFIL;CIALIS;IC 351;(6r,12ar)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione;TADALAFIL(CIALIS);Taladafil (cialis);Cialis/taladafil;Cialis(IC351)
Properties
Melting point:298-300°C
alpha D20 +71.0°
Flash point:2℃
storage temp. Hygroscopic, -20?C Freezer, Under Inert Atmosphere
solubility DMSO: soluble20mg/mL, clear
color white to beige
InChIKeyWOXKDUGGOYFFRN-IIBYNOLFSA-N
Safety Information
Symbol(GHS)


Description
Tadalafil (Tadalifil citrate), a phosphodiesterase type 5 inhibitor, is used to treat erectile dysfunction (ED) and decreased libido in males. Tadalafil works by aiding relaxation of blood vessels and increasing blood flow in the penis during sexual arousal, resulting in improved erectile function. Tadalafil is much longer lasting. Effects can be felt anywhere between 36-48 hours.
Action: Tadalafil improves erectile function significantly, possibly increased sexual activity, and is very safe.
There are limited side effects associated with its use. The most common side effects are headache, upset stomach, back pain, and muscle aches, and usually subside with in a few hours.
Tadalafil was also found to be significantly higher at the end of the month, due to increased sexual activity.
COA
| Items | Enterprise | Result |
| Description | Off-white or white crystalline powder | White crystalline powder |
| Identification | IRHPLC | Conform to standard |
| Loss on drying | ≤0.5% | 0.1% |
| Residue on ignition | ≤0.1% | 0.03% |
| Heavy metals | ≤0.002% | <0.002% |
| Related substances | Individual impurity≤0.1% | 0.03% |
| Total impurities≤0.3% | ≤0.3% | |
| Assay | 97.5~102.5% | 99.82% |
Function & Usage
Tadalafil is used to treat male sexual function problems (impotence or erectile dysfunction) by blocking a certain enzyme (phosphodiesterase-PDE5) in the body. In combination with sexual stimulation, tadalafil helps blood flow into the penis to achieve and maintain an erection.
Tadalafil is also used in both men and women to treat the symptoms of pulmonary arterial hypertension. This is high blood pressure that occurs in the main artery that carries blood from the right side of the heart (the ventricle) to the lungs. When the smaller blood vessels in the lungs become more resistant to blood flow, the right ventricle must work harder to pump enough blood through the lungs.
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