Abstract

Norethisterone, norethindrone or 19-nor-17α -ethynyltestosterone is a molecule used in some combined oral contraceptive pills, progestogen only pills and is also available as a stand-alone drug. It is a progestogen and can be used to treat premenstrual syndrome, painful periods, abnormal heavy bleeding, irregular periods, menopausal syndrome (in combination with oestrogen), or to postpone a period.

It is also commonly used to help prevent uterine hemorrhage in complicated non-surgical or pre-surgical gynecologic cases. Norethindrone was the first orally highly active progestin to be synthesized. It was synthesized for the first time by chemists Luis Miramontes, Carl Djerassi, and George Rosenkranz at Syntex in Mexico City in 1951. It was the progestin used in one of the first three oral contraceptives. Its related ester, norethisterone acetate, is used for the same indications.

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Application

Norethisterone contains a hormone which is similar to the hormoneprogestogen that is naturally produced by the body. It is used to treat a number of menstrual cycle disorders. Norethisterone is also used to help treat breast cancer.

This leaflet discusses norethisterone when it is used to treat heavy periods. Although other treatment options for heavy periods are more common, norethisterone is sometimes considered if other treatments have not worked or are unsuitable. Norethisterone treatment aims to reduce the amount of blood loss. When taking norethisterone in this way, it does not act as a contraceptive.

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