Description:
L-thyroxine is a synthetic thyroid hormone that is chemically identical to thyroxine (T4), which is
naturally secreted by the follicular cells of the thyroid gland. It is used to treat thyroid hormone
deficiency, and occasionally to prevent the recurrence of thyroid cancer. Like its naturally
secreted counterpart, levothyroxine is a chiral compound in the L-form. The related drug
dextrothyroxine (D-thyroxine) was used in the past as a treatment for hypercholesterolemia
(elevated cholesterol levels) but was withdrawn due to cardiac side effects. It is on the World
Health Organization's List of Essential Medicines, a list of the most important medication needed
in a basic health system.
Application:
L-thyroxine is typically used to treat hypothyroidism,and is the treatment of choice for patients with
hypothyroidism, who often require lifelong thyroid hormone therapy.It may also be used to treat
goiter via its ability to lower thyroid-stimulating hormone (TSH), a hormone that is considered
goiter-inducing. L-thyroxine is also used as interventional therapy in patients with nodular thyroid
disease or thyroid cancer to suppress thyroid-stimulating hormone (TSH) secretion.
Levothyroxine is widely used by bodybuilders and fitness addicts on pre-competition cycle in
order to get relief, also used by overweighed people to reduce weight. It increases metabolism
and produces general stimulating effects. However, this substance should be used wisely.
Levothyroxine for systemic administration is available as an oral tablet, an intramuscular injection,
and as a solution for intravenous infusion. Furthermore, levothyroxine is available as both brand-
name and generic products. While the United States Food and Drug Administration (FDA)
approved the use of generic levothyroxine for brand-name levothyroxine in 2004, the decision
was met with disagreement by several medical associations.The American Association of
Clinical Endocrinologists (AACE), the Endocrine Society, and the American Thyroid Association
did not agree with the FDA that brand-name and generic formulations of levothyroxine were
bioequivalent.] As such, it was recommended that patients be started and kept on either brand-
name or generic levothyroxine formulations and not changed back and forth from one to the
other.For patients who do switch products, it is recommended that their TSH and free T4 levels
be tested after six weeks to check that they are within normal range.

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