Description:

Minoxidil is an antihypertensive vasodilator medication. It also slows or stops hair loss and

promotes hair regrowth. Now off-patent, it is available over-the-counter for the treatment of

androgenic alopecia.Widely used for the treatment of hair loss, it has been proven clinically

effective in both the prevention of loss and in establishing varying degrees of hair re-growth in

males and females suffering pattern baldness. Minoxidil must be used indefinitely for continued

support of existing hair follicles and the maintenance of any experienced hair regrowth.

Application:

Minoxidil was the first drug approved by the FDA for the treatment of androgenetic alopecia (hair

loss). Before that, minoxidil had been used as vasodilator drug prescribed as oral tablet to treat

high blood pressure, with side effects that included hair growth and reversal of male baldness. In

the 1980s, UpJohn Corporation came out with a topical solution of 2% minoxidil, called Rogaine,

for the specific treatment of androgenetic alopecia. Since the 1990s, numerous generic forms of

minoxidil have become available to treat hair loss while the oral form is still used to treat high

blood pressure.

The popularity hair loss treatment is due to the general preference in the overall population for the

cosmetic appearance of a full head of hair. Minoxidil is used to stimulate hair growth in areas of

the scalp that have stopped growing hair. As of early 2001, the exact mechanism of action of

minoxidil is not known.

Usage:

Minoxidil, applied topically, is widely used for the treatment of hair loss. It is effective in helping

promote hair growth in both males and females with androgenic alopecia. About 40% of men

experience hair regrowth after 3-6 months. Minoxidil must be used indefinitely for continued

support of existing hair follicles and the maintenance of any experienced hair regrowth. It is the

only topical product that is FDA approved for androgenic hair loss. Treatments usually include a

5% concentration solution that is designed for men, and a 2% concentration solution for women.

Minoxidil is a clinical oral medication for lowering blood pressure, also known as minoxidil,

piperazine pyrimidine diamine, buck fixed, Minoxidil blood given, are potassium channel opener,

can direct relaxation of vascular smooth muscle, there is a strong expansion of the role of small

arteries, the peripheral resistance decreased, blood vessels expand, blood pressure, and had no

effect on the capacitance vessels, it can promote venous return.

Meanwhile, the reflex regulation and positive frequency effect, can increase cardiac output and

heart rate, but does not cause orthostatic hypotension. Clinic for refractory hypertension and renal

hypertension treatment. Can also be used for other antihypertensive drugs ineffective severe

hypertension, but the need to avoid sodium retention diuretics and β -blockers can be combined

to make increased efficacy, adverse reactions decreased.

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