Medical Local Anesthetic Drugs Tetracaine hydrochloride Tetracaine Hcl CAS No.:136-47-0

Medical Local Anesthetic Drugs Tetracaine hydrochloride Tetracaine Hcl CAS No.:136-47-0

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Basic information


Product Name:Tetracaine hydrochloride
Synonyms:

L AND OCAIN HYDROCHLORIDE;INTERCAIN HYDROCHLORIDE;

MEETHOBALM HYDROCHLORIDE;

2-(DIMETHYLAMINO)ETHYL 4-(N-BUTYLAMINO)BENZOATE HYDROCHLORIDE;

2-DIMETHYLAMINOETHYL ESTER OFP-BUTYLAMINOBENZOIC

ACID HYDROCHLORIDE;4-(N-BUTYLAMINO)BENZOIC ACID 2-(DIMETHYLAMINO)

ETHYL ESTER HYDROCHLORIDE;4-[BUTYLAMINO]BENZOIC ACID-2-

[DIMETHYLAMINO]ETHYL ESTER HYDROCHLORIDE;

4-BUTYLAMINOBENZOIC ACID DIMETHYLAMINOETHYL ESTER HCL

CAS:136-47-0
MF:C15H25ClN2O2
MW:300.82
EINECS:205-248-5
Product Categories:

API intermediates;Sodium channel;Amines;Aromatics;Intermediates & Fine Chemicals;

Pharmaceuticals;Pharmaceutical intermediate;PONTOCAINE;Local anesthetic

UsageA local anesthetic used topically in opthalmology.
ChemicalWhite Solid


Tetracaine hydrochloride---Description


  • Tetracaine hydrochloride is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.


Tetracaine hydrochloride---Application


  • Tetracaine hydrochloride (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.

  • Tetracaine hydrochloride,In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.