Human Growth Polypeptide Hormones PT-141 for Sexual Dysfunction treatment

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Description:

Name	PT-141
Other name	Bremelanotide
Specification	10mg/ vial
Molecular formula	C50H68N14O10
Molar Mass	1025.2
Sequence	Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys-OH)
One Letter Sequence	Ac-Nle-cyclo[DH(d-F)RWK]
Physical Apperance	White Powder
Form & Formulations	Sterile Filtered white lyophilized (freeze-dried)
Stability	2 months at room temperature 24 months from date of receipt, 20 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, 20 to 70 °C under sterile conditions after reconstitution.
Purity	﹥98% by RP-HPLC
Storage	Lyophilized PT-141 is stable at room temperature for 90 days,however it should be stored in a freezer below -8C for any extended period of time. After reconstituting PT-141 should be refrigerated at temperatures not to exceed 36 F.

Introduction:

PT-141 is the first of a new class of drugs called melanocortin agonists being developed to treat sexual dysfunction. The mechanism of action of PT-141 may offer significant safety and efficacy benefits over currently available products because it acts on the pathway that controls sexual function without acting directly on the vascular system. Clinical data indicates that PT-141 may be effective in treating a broad range of patients suffering from ED. The nasal formulation of PT-141 being developed is as convenient as oral treatments, is more patient-friendly than invasive treatments for ED, such as injections and trans-urethral pellets, and appears to result in a rapid onset of action.

PT-141 usage:

PT-141, or bremelanotide, belongs to the new class of synthetic proteins that work as melanocortin agonists. Bremelanotide is a research peptide developed by United States. PT-141 functions by activating the melanocortin 1 receptor and MC4R namely. PT-141 was shown to be effective in treating sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder). Unlike Viagra and other related medications, it does not act upon the vascular system, but directly increases sexual desire via the nervous system.

PT-141 is a melanocortin based peptide that has shown effectiveness in clinical studies on both male and female rats. It can treat Sexual Dysfunction, Male rats have shown erectile response with doses as low as 1-2 mgs whereas most female rats have shown positive results with higher doses around 2-3 mgs.

Bremelanotide comes in 10mg and 2mg vial sizes. Peptides photographed at right are synthesized by the same laboratory, contain no filler and therefore the difference is visible. Freeze dried Melanotan peptides (PT-141) are very durable and stable. Most PT-141 comes in the industry standard 10mg size. The 2mg PT-141 is used more as a travel peptide or couples dose. As a lifestyle peptide, the 10mg product is a lot to consume and may offer up to 20 doses when dosing light. The PT-141 peptide reconstituted with bacteriostatic water remains potent in the fridge for months.